Antileukemic Activity and Chemical Constituents of Some Zingiberaceae Species

被引：0
|
作者：
Sukari, M. A. [1 ]
Tang, S. W. [1 ]
Neoh, B. K. [1 ]
Ee, G. C. L. [1 ]
Rahmani, M. [1 ]
机构：
[1] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor Darul, Malaysia
来源：
ASIAN JOURNAL OF CHEMISTRY | 2010年 / 22卷 / 10期
关键词：
Zingiberaceae; Antileukemic; Alpinia; Zingiber; Kaempferia; KAEMPFERIA-GALANGA; PRINCIPLES; RHIZOME;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Crude extracts of various solvents from six species (genus Alpinia, Zingiber, Kaempferia) of Zingiberaceae family have been chosen for the in vitro cytotoxic activity screening against the inhibition of HL-60 cell line (Human promyelocytic leukemia). Eight extracts (44%) were found to have cytotoxic activity with IC50 values less than 30 mu g/mL, with Alpinia galanga showing the most prominent antileukemic activity. Further isolation work on Kaempferia galanga has yielded ethyl p-methoxy-trans-cinnamate (1), p-methoxy-trans-cinnamic acid (2) besides beta-sitosterol.
引用
收藏
页码：7891 / 7896
页数：6
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