Pd-catalyzed [3+2] cycloaddition of cyclic ketimines and trimethylenemethanes toward N-fused pyrrolidines bearing a quaternary carbon

被引：5

作者：

Choi, Seoung-Mi ^{[1
]}

Do Kim, Kyeong ^{[1
]}

Park, Jong-Un ^{[1
]}

Xuan, Zi ^{[1
]}

Kim, Ju Hyun ^{[1
]}

机构：

[1] Gyeongsang Natl Univ, Res Inst Nat Sci, Dept Chem BK21 Four, Jinju 52828, South Korea

来源：

RSC ADVANCES | 2021年 / 12卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

BAYLIS-HILLMAN CARBONATES; ENANTIOSELECTIVE SYNTHESIS; NITROGEN-HETEROCYCLES; ASYMMETRIC-SYNTHESIS; CONSTRUCTION; CYCLOPROPANES; 1-AZADIENES; KETONES; ANNULATION; STRATEGY;

D O I：

10.1039/d1ra08579d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Pd-catalyzed [3 + 2] cycloaddition of N-sulfonyl cyclic ketimines and trimethylenemethanes (TMM) was developed that afforded N-fused pyrrolidines bearing a quaternary carbon. Under mild reaction conditions, structurally diverse N-sulfonyl cyclic imines, including sulfamate-fused aldimines, aryl- or styryl-substituted sulfamate-derived ketimines, and N-sulfonyl cyclic ketimines, were tolerated as reactants, affording N-fused pyrrolidines with high efficiency.

引用

页码：785 / 789

页数：5

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