Intraventricular infusion of basic fibroblast growth factor (bFGF) in the MPTP-treated common marmoset

被引:0
|
作者
Pearce, RKB
Collins, P
Jenner, P
Emmett, C
Marsden, CD
机构
[1] UNIV LONDON KINGS COLL,DIV BIOMED SCI,PHARMACOL GRP,NEURODEGENERAT DIS RES CTR,LONDON SW3 6LX,ENGLAND
[2] SYNTEX INC,INST PHARMACOL,DEPT NEUROSCI,RES,PALO ALTO,CA
[3] UNIV LONDON,NATL HOSP NEUROL & NEUROSURG,INST NEUROL,DEPT CLIN NEUROL,LONDON WC1,ENGLAND
关键词
neurotrophic factors; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); Parkinson's disease; primate;
D O I
10.1002/(SICI)1098-2396(199607)23:3<192::AID-SYN8>3.0.CO;2-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Basic fibroblast growth factor (bFGF) prevents damage to the nigrostriatal system in rodents. We now report the effects of bFGF administered by intraventricular infusion to adult common marmosets (Callithrix jacchus) previously rendered parkinsonian by the administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Infusion commenced 10 weeks after MPTP treatment and the animals received bFGF in low (1.8 mu g/l), medium (18 mu g/l), or high (180 mu g/l) doses over a 28-day period. At weekly intervals, automated activity measurements, behavioral disability scoring, and videotape analyses were made. There was no improvement in the motor deficits exhibited by MPTP-treated common marmosets receiving bFGF infusion compared to vehicle-treated controls. Three of five high dose animals showed neurological impairment prior to the end of the study. No significant differences were found between control and bFGF-infused MPTP-treated common marmosets with respect to nigral tyrosine hydroxylase immunoreactive cell counts and striatal [H-3]mazindol binding. All high dose animals showed hydrocephalus which was also observed in four other animals receiving bFGF. Histological examination revealed proliferation of the choroid plexus and ependyma which was most marked in the high dose animals. Adverse effects, in the form of hydrocephalus and neurological deterioration, were presumably secondary to an ependymal and choroid plexus reaction induced by bFGF. (C) 1996 Wiley-Liss, Inc.
引用
收藏
页码:192 / 200
页数:9
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