Association of Decreased Left Atrial Strain and Strain Rate with Stroke in Chronic Atrial Fibrillation

Background: The objective of this study was to investigate myocardial deformation of the left atrium (LA) assessed by two-dimensional speckle tracking echocardiography in patients with permanent atrial fibrillation (AF) and its value for risk stratification for stroke. Methods: We recruited 66 consecutive patients with permanent AF who were referred to our echocardiography laboratory for evaluation. These patients were divided into two groups according to the presence of previous stroke or not. Results: Peak positive longitudinal strain (LASp) during atrial filling, peak strain rate in the reservoir phase of LA (LASRr), and peak strain rate in the conduit phase (LASRc) were identified from LA strain and strain rate curves. The ratio of peak early filling velocity (E) of mitral inflow to early diastolic annulus velocity (E') of the medial annulus (E/E') was calculated. LASp (10.44% +/- 4.2% vs. 15.69% +/- 5.1%, P < .001), LASRr (1.09 +/- 0.27 1/s vs. 1.37 +/- 0.32 1/s, P = .001), and LASRc (-1.28 +/- 0.38 1/s vs. -1.62 +/- 0.43 1/s, P = .002) were significantly lower in patients with AF with stroke than those without stroke. By multivariate analysis controlling for age, LA volume index, and left ventricular ejection fraction, LASp (OR 0.787,95% CI, 0.639-0.968, P = .023) and LASRr (OR 0.019,95% CI, 0.001-0.585, P = .023) were independently associated with stroke but not LASRc, E', and E/E' ratio. Conclusion: Decreased LASp and LASRr were independently associated with stroke in patients with permanent AF. (J Am Soc Echocardiogr 2011;24:513-9.)