An efficient oxa-Michael addition to diethyl vinylphosphonate under mild reaction conditions

被引：12

作者：

Baszczynski, Ondrej ^{[1
]}

Jansa, Petr ^{[1
]}

Dracinsky, Martin ^{[1
]}

Kaiser, Martin Maxmilian ^{[1
]}

Spacek, Petr ^{[1
]}

Janeba, Zlatko ^{[1
]}

机构：

[1] Acad Sci Czech Republic, Inst Organ Chem & Biochem, Vvi, CR-16610 Prague 6, Czech Republic

来源：

RSC ADVANCES | 2012年 / 2卷 / 04期

关键词：

ACYCLIC NUCLEOSIDE PHOSPHONATES; HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE; DERIVATIVES; INHIBITION; RESISTANCE; ANALOGS; TARGET; WATER; ACIDS; DNA;

D O I：

10.1039/c2ra00938b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An oxa-Michael addition of various secondary and branched primary alcohols to diethyl vinylphosphonate was systematically studied and optimized. This efficient method precedes using of harsh reaction conditions (e.g. strong bases, high temperatures) and gains access to an important class of biologically active compounds in one step.

引用

页码：1282 / 1284

页数：3

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