Increasing titers in mammalian cell culture has recently shifted the focus of process development efforts towards improving the economics of product recovery and purification processes. Some argue that a paradigm shift may be required to ensure timely and cost-effective delivery of future antibody candidates. This paper discusses the key process economic drivers and the impact of scale and titer on downstream processing (DSP) economic trade-offs.
机构:
Univ New Brunswick, Dept Econ, Fredericton, NB E3B 5A3, CanadaUniv West Indies, Sir Arthur Lewis Inst Social & Econ Studies, St Augustine, Trinidad Tobago
Chowdhury, Murshed
Arjoon, Vaalmikki
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机构:
Univ West Indies, Dept Management Studies, St Augustine, Trinidad TobagoUniv West Indies, Sir Arthur Lewis Inst Social & Econ Studies, St Augustine, Trinidad Tobago