Genetically haploidentical stem cell transplantation for acute leukemia

被引：19
|
作者：
Rowe, JM [1 ]
Lazarus, HM
机构：
[1] Technion Israel Inst Technol, Dept Hematol & Bone Marrow Transplantat, Rambam Med Ctr, IL-31096 Haifa, Israel
[2] Univ Hosp Cleveland, Ireland Canc Ctr, Dept Med, Cleveland, OH 44106 USA
[3] Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel
来源：
BONE MARROW TRANSPLANTATION | 2001年 / 27卷 / 07期
关键词：
haploidentical transplantation; acute leukemia;
D O I：
10.1038/sj.bmt.1702856
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Genetically haploidentical stem cell transplants have been performed for several decades, mostly for patients with advanced acute leukemia. Such transplants are an option for those patients who do not have a histocompatible sibling donor. The historical data have been disappointing due to graft-versus-host disease, engraftment failure and delayed immune reconstitution. Recent modifications and new technological developments have led to more encouraging clinical results, Haploidentical transplantation is immediately available to the majority of patients with acute leukemia and is an acceptable alternative to matched unrelated donor transplantation.
引用
收藏
页码：669 / 676
页数：8
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