Protein conformation dictates prion strain

被引：15
|
作者：
Aguzzi, A [1 ]
机构：
[1] Univ Spital Zurich, Inst Neuropathol, CH-8091 Zurich, Switzerland
来源：
NATURE MEDICINE | 1998年 / 4卷 / 10期
关键词：
D O I：
10.1038/2621
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new conformation-based immunoassay provides a smart and sensitive way of differentiating between strains of prions, the infectious particles believed to cause spongiform encephalopathy (pages 1157–1165 ).
引用
收藏
页码：1125 / 1126
页数：2
相关论文
共 50 条
  • [41] Conformation-Specific Association of Prion Protein Amyloid Aggregates with Tau Protein Monomers
    Ziaunys, Mantas
    Mikalauskaite, Kamile
    Krasauskas, Lukas
    Smirnovas, Vytautas
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (11)
  • [42] Prion protein conformation determines the clinical and pathological phenotype of fatal insomnia
    Mastrianni, JA
    Nixon, R
    Layzer, R
    DeArmond, S
    Prusiner, S
    ANNALS OF NEUROLOGY, 1998, 44 (06) : 990 - 990
  • [43] The information embedded into protein conformation: the mammalian prion protein is not the only one which "prionized"
    Toupet, Karine
    Lehman, Sylvain
    M S-MEDECINE SCIENCES, 2009, 25 (03): : 307 - 310
  • [44] Atypical Prion Protein Conformation in Familial Prion Disease with PRNP P105T Mutation
    Polymenidou, Magdalini
    Prokop, Stefan
    Jung, Hans H.
    Hewer, Ekkehard
    Peretz, David
    Moos, Rita
    Tolnay, Markus
    Aguzzi, Adriano
    BRAIN PATHOLOGY, 2011, 21 (02) : 209 - 214
  • [45] Novel prion protein conformation and glycotype in Creutzfeldt-Jakob disease
    Zanusso, Gianluigi
    Polo, Alberto
    Farinazzo, Alessia
    Nonno, Romolo
    Cardone, Franco
    Di Bari, Michele
    Ferrari, Sergio
    Principe, Serena
    Gelati, Matteo
    Fasoli, Elisa
    Fiorini, Michele
    Prelli, Frances
    Frangione, Blas
    Tridente, Giuseppe
    Bentivoglio, Marina
    Giorgi, Alessandra
    Schinina, Maria Eugenia
    Maras, Bruno
    Agrimi, Umberto
    Rizzuto, Nicola
    Pocchiari, Maurizio
    Monaco, Salvatore
    ARCHIVES OF NEUROLOGY, 2007, 64 (04) : 595 - 599
  • [46] Regulation of the cellular prion protein gene expression depends on chromatin conformation
    Cabral, ALB
    Lee, KS
    Martins, VR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (07) : 5675 - 5682
  • [47] Polymorphism at 129 dictates metastable conformations of the human prion protein N-terminal β-sheet
    Paz, S. Alexis
    Vanden-Eijnden, Eric
    Abrams, Cameron F.
    CHEMICAL SCIENCE, 2017, 8 (02) : 1225 - 1232
  • [48] Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination
    Kang, Hae-Eun
    Bian, Jifeng
    Kane, Sarah J.
    Kim, Sehun
    Selwyn, Vanessa
    Crowell, Jenna
    Bartz, Jason C.
    Telling, Glenn C.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295 (30) : 10420 - 10433
  • [49] Strain conformation controls the specificity of cross-species prion transmission in the yeast model
    Grizel, Anastasia V.
    Rubel, Aleksandr A.
    Chernoff, Yury O.
    PRION, 2016, 10 (04) : 269 - 282
  • [50] Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination
    Kang H.-E.
    Bian J.
    Kane S.J.
    Kim S.
    Selwyn V.
    Crowell J.
    Bartz J.C.
    Telling G.C.
    Telling, Glenn C. (glenn.telling@colostate.edu), 1600, American Society for Biochemistry and Molecular Biology Inc. (295): : 10420 - 10433
12345