Analysis of C-850T and G-308A polymorphisms of the tumor necrosis factor-α gene in Maya-Mestizo women with preeclampsia

被引：18
|
作者：
Canto-Cetina, Thelma
Canizales-Quinteros, Samuel
de la Chesnaye, Elsa
Coral-Vazquez, Ramon
Mendez, Juan Pablo
Canto, Patricia
机构：
[1] Inst Mexicano Seguro Social, Coordinac Invest Salud, Ctr Med Nacl Siglo 21, Unidad Invest Med Biol Desarrollao, Mexico City 06703, DF, Mexico
[2] Inst Mexicano Seguro Social, Hosp Pediat, Ctr Med Nacl Siglo 21, Unidad Invest Med Genet Humana, Mexico City, DF, Mexico
[3] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Biol Mol & Med Genom, Mexico City, DF, Mexico
[4] Ctr Invest Reg Dr Hideyo Noguchi, Dept Salud Reprod & Genet, Reprod Biol Lab, Mexico City, DF, Mexico
来源：
HYPERTENSION IN PREGNANCY | 2007年 / 26卷 / 03期
关键词：
C-850T polymorphism; G-308A polymorphism; Maya-Mestizo women; promoter of the TNF-alpha; preeclampsia; TNF-ALPHA; INSULIN-RESISTANCE; EXPRESSION; HAPLOTYPE; INTERLEUKIN-1-BETA; ASSOCIATION; FREQUENCIES; PREGNANCY; CYTOKINES; MARKERS;
D O I：
10.1080/10641950701372732
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
To determine whether polymorphisms in the TNF-alpha promoter gene are associated with preeclampsia. Methods: 105 women with preeclampsia and 200 controls were genotyped for the G-308A and C-850T polymorphisms by RFLP. Differences in allele, genotype, and haplotype frequencies between groups were assessed. Results: The genotypic and allelic distribution of both polymorphisms was similar between groups. Moreover, the estimated overall pair of loci haplotype frequencies did not differ significantly. Conclusion: We did not find any association between these polymorphisms and the risk for preeclampsia. However, we found that both the genotypic and allelic distribution in our population differed from those reported in other populations.
引用
收藏
页码：283 / 291
页数：9
相关论文
共 50 条
  • [31] Tumor necrosis factor-α-308 G/A and interleukin 10-1082 A/G gene polymorphisms in patients with acne vulgaris
    Al-Shobaili, Hani A.
    Salem, Tarek A.
    Alzolibani, Abdullateef A.
    Al Robaee, Ahmad
    Settin, Ahmad A.
    JOURNAL OF DERMATOLOGICAL SCIENCE, 2012, 68 (01) : 52 - 55
  • [32] Tumor necrosis factor alpha gene G-308A and G-238A polymorphisms and risk of coeliac disease in Type 1 diabetic children
    Krikovszky, D
    Vásárhelyi, B
    Arató, A
    Treszl, A
    Tulassay, T
    Madácsy, L
    DIABETOLOGIA, 2002, 45 : A112 - A112
  • [33] Association between the tumor necrosis factor-α-308 G/A gene polymorphism and migraine
    Rainero, I
    Grimaldi, LME
    Salani, G
    Valfrè, W
    Rivoiro, C
    Savi, L
    Pinessi, L
    NEUROLOGY, 2004, 62 (01) : 141 - 143
  • [34] Tumor necrosis factor-α-308 promoter and p53 codon 72 gene polymorphisms in women with leiomyomas
    Hsieh, YY
    Chang, CC
    Tsai, FJ
    Lin, CC
    Yeh, LS
    Tsai, CH
    FERTILITY AND STERILITY, 2004, 82 : 1177 - 1181
  • [35] Analysis of tumor necrosis factor-α-308 and lymphotoxin-α+252 gene polymorphisms in Taiwanese patients with periodontitis
    Ho, Ya-Ping
    Lin, Ying-Chu
    Yang, Yi-Hsin
    Chou, Yu-Hsiang
    Ho, Kun-Yen
    Wu, Yi-Min
    Tsai, Chi-Cheng
    JOURNAL OF DENTAL SCIENCES, 2015, 10 (03) : 316 - 322
  • [36] Association of tumor necrosis factor alpha gene polymorphism G-308A with pseudoexfoliative glaucoma in the Pakistani population
    Khan, Muhammad Imran
    Micheal, Shazia
    Rana, Noreen
    Akhtar, Farah
    den Hollander, Anneke I.
    Ahmed, Asifa
    Qamar, Raheel
    MOLECULAR VISION, 2009, 15 (302): : 2861 - 2867
  • [37] Analysis of tumor necrosis factor-α production and polymorphisms of the tumor necrosis factor-α gene in individuals with a history of Kawasaki disease
    Kamizono, S
    Yamada, A
    Higuchi, T
    Kato, H
    Itoh, K
    PEDIATRICS INTERNATIONAL, 1999, 41 (04) : 341 - 345
  • [38] Gene-disease association study of tumor necrosis factor-α G-308A gene polymorphism with risk of major depressive disorder: A systematic review and meta-analysis
    Wang, Xin
    Zhang, Hongxiu
    Cao, Xianling
    Shi, Wei
    Zhou, Xiaoyu
    Chen, Qian
    Ma, Ke
    BRAIN AND BEHAVIOR, 2020, 10 (06):
  • [39] The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with migraine without aura
    Mazaheri, Shahir
    Hajilooi, Mehrdad
    Rafiei, Alireza
    JOURNAL OF NEUROLOGY, 2006, 253 (12) : 1589 - 1593
  • [40] The -308G/A tumor necrosis factor-α gene dimorphism:: A risk factor for unstable angina
    Bernard, V
    Pillois, X
    Dubus, I
    Benchimol, D
    Labouyrie, JP
    Couffinhal, T
    Coste, P
    Bonnet, J
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2003, 41 (04) : 511 - 516
12345