Intracellular regulation of heterotrimeric G-protein signaling modulates vascular smooth muscle cell contraction

被引:13
|
作者
Bastin, Guillaume [1 ]
Heximer, Scott P. [1 ]
机构
[1] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada
基金
加拿大健康研究院;
关键词
G-protein coupled receptor; Vascular smooth muscle cells; Heterotrimeric GTP-binding proteins; RCS proteins; Blood pressure; GTPASE-ACTIVATING PROTEINS; BLOOD-PRESSURE REGULATION; KINASE-C; ANGIOTENSIN-II; MYOGENIC TONE; MYOSIN PHOSPHORYLATION; CEREBRAL-ARTERIES; CA2+ SENSITIVITY; RHO-KINASE; WALL CA2+;
D O I
10.1016/j.abb.2011.05.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The contractile function of vascular smooth muscle cells within the media of resistance arterioles is tightly connected to the role of these blood vessels in the maintenance of blood pressure homeostasis. Thus, much effort has been made to understand the intracellular signaling pathways that control vascular smooth muscle cell contractility with the aim that this knowledge will provide important clues for reducing the impact of uncontrolled blood pressure in our society. A key set of surface receptors, the G-protein coupled receptors, has been widely associated with the regulation of vascular smooth muscle cell contractility. Indeed, many of the current treatments for hypertension involve selective inhibition of these receptors. More recently, we have begun to understand the cellular mechanisms whereby G-protein coupled pathways are connected to the contractile machinery of the vascular smooth muscle cells. What has emerged is a view where there are multiple intracellular control points for G-protein signaling that coordinate and focus the extracellular stimuli into meaningful physiologic responses. This work will examine some of the recent advances in our understanding of G-protein signaling and its regulation of contractile function in vascular smooth muscle cells. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:182 / 189
页数:8
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