Fiber-Optic Raman Spectrum Sensor for Fast Diagnosis of Esophageal Cancer

被引：5

作者：

Dai, Jianhua ^{[1
]}

He, Xiu ^{[2
]}

Li, Zhuoyue ^{[2
]}

Li, Kang ^{[2
]}

Yang, Tingting ^{[2
]}

Ran, Zengling ^{[2
]}

Yin, Lijian ^{[1
]}

Chen, Yao ^{[1
]}

Zou, Xiang ^{[3
]}

Fang, Dianchun ^{[1
]}

Peng, Guiyong ^{[1
]}

机构：

[1] Army Med Univ, Southwest Hosp, Inst Digest Dis, Chongqing 40038, Peoples R China

[2] Univ Elect Sci & Technol China, Minist Educ, Key Lab Opt Fiber Sensing & Commun, Fiber Opt Res Ctr, Chengdu 611731, Sichuan, Peoples R China

[3] Zolix Instruments Co Ltd, Beijing 101102, Peoples R China

来源：

PHOTONIC SENSORS | 2019年 / 9卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Fiber-optic; Raman spectrum; esophageal cancer; ENDOSCOPIC SUBMUCOSAL DISSECTION; BARRETTS-ESOPHAGUS; SPECTROSCOPY; TISSUE;

D O I：

10.1007/s13320-018-0516-7

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

A fiber-optic Raman spectrum sensor system is used for the fast diagnosis of esophageal cancer during clinical endoscopic examination. The system contains a 785 nm exciting laser, a Raman fiber-optic probe with 7 large core fibers and a focus lens, and a highly sensitive spectrum meter. The Raman spectrum of the tissue could be obtained within 1 second by using such a system. A signal baseline removal and denoising technology is used to improve the signal quality. A novel signal feature extraction method for differentiating the normal and esophageal cancer tissues is proposed, based on the differences in half-height width (HHW) in 1200 cm(1) to 1400 cm(1) frequency band and the ratios of the spectral integral energy between 1600 cm(1) - 1700 cm(1) and 1500 cm(1) - 1600 cm(1) band. It shows a high specificity and effectivity for the diagnosis of esophageal cancer.

引用

页码：53 / 59

页数：7

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