Anti-platelet therapy: ADP receptor antagonists

被引：85

作者：

Wijeyeratne, Yanushi Dullewe ^{[1
]}

Heptinstall, Stan ^{[1
]}

机构：

[1] Univ Nottingham, Div Cardiovasc Med, Sch Clin Sci, Queens Med Ctr, Nottingham NG7 2UH, England

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2011年 / 72卷 / 04期

关键词：

anti-platelet; cangrelor; clopidogrel; platelet; P2Y12; prasugrel; ticagrelor; ACUTE CORONARY SYNDROMES; PLATELET-FUNCTION; P2Y(12) RECEPTOR; ADENOSINE-DIPHOSPHATE; ANTITHROMBOTIC AGENTS; DOSE CLOPIDOGREL; P2; RECEPTORS; HUMAN BLOOD; INHIBITION; AGGREGATION;

D O I：

10.1111/j.1365-2125.2011.03999.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided that there are no adverse effects on haemostasis. Here we describe the ADP receptor antagonists that are available and in development. We also consider their mode of action and ask whether there are additional mechanisms through which they exert their inhibitory effects on platelet function.

引用

页码：647 / 657

页数：11

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