The first proline-catalyzed Friedlander annulation: Regioselective synthesis of 2-substituted quinoline derivatives

被引：38
|
作者：
Jiang, Biao [1 ]
Dong, Jia-jia [1 ]
Jin, Yun [1 ]
Du, Xiao-long [1 ]
Xu, Min [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 2008卷 / 16期
关键词：
aldol reactions; quinoline; cyclization; proline;
D O I：
10.1002/ejoc.200800121
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first proline-catalyzed Friedlander annulation for the synthesis of 2-substituted 4-trifluoromethyl quinoline derivatives is described. Excellent re gio selectivity as well as good yields were shown in a variety of cases, and a tandem aldol-cyclization pathway might be involved. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
引用
收藏
页码：2693 / 2696
页数：4
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