The relationship between TIGIT+ regulatory T cells and autoimmune disease

被引：28
|
作者：
Lee, Darren J. [1 ,2 ]
机构：
[1] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Dean McGee Eye Inst, Oklahoma City, OK 73107 USA
[2] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Dean McGee Eye Inst, Oklahoma City, OK 73190 USA
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2020年 / 83卷
基金：
美国国家卫生研究院;
关键词：
POLIOVIRUS RECEPTOR; INHIBITORY MOTIF; EXPRESSION; ADHESION; PROTEIN; DOMAIN; ENTEROPATHY; TOLERANCE; MECHANISM; NECTINS;
D O I：
10.1016/j.intimp.2020.106378
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of regulatory T cells (Treg cell) in controlling autoimmune disease is an area of intense study. As such, the characterization and understanding the function of Treg markers has the potential to provide a considerable impact in developing treatments and understanding the pathogenesis of autoimmune diseases. One such inhibitory Treg cell marker that has been recently discovered is T cell immunoglobulin and ITIM domain (TIGIT). In this review, we discuss what is known about the expression and function of TIGIT on Treg cells, and we discuss the relationship between TIGIT expressing Treg cells and different autoimmune diseases such as atopic dermatitis, autoimmune thyroiditis, type 1 diabetes, autoimmune uveitis, aplastic anemia, multiple sclerosis, systemic lupus erythematosus, arthritis, and colitis.
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页数：5
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