Soluble CD40 ligand in acute coronary syndrome in cocaine users

被引：0

作者：

Dominguez-Rodriguez, Alberto ^{[2
]}

Abreu-Gonzalez, Pedro ^{[3
]}

Enjuanes-Grau, Cristina ^{[2
]}

Juarez-Prera, Ruben ^{[2
]}

Arroyo-Ucar, Eduardo ^{[2
]}

Burillo-Putze, Guillermo ^{[1
]}

机构：

[1] Hosp Univ Canarias, Serv Urgencias, Tenerife 38320, Spain

[2] Hosp Univ Canarias, Serv Cardiol, Tenerife 38320, Spain

[3] Univ La Laguna, Dept Fisiol, Tenerife, Spain

来源：

EMERGENCIAS | 2011年 / 23卷 / 02期

关键词：

Cocaine; Inflammation; Unstable angina; Atherosclerosis; EMERGENCY-DEPARTMENT; INFLAMMATION; RISK;

D O I：

暂无

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background and objectives: The soluble CD40 ligand (sCD40L) expressed on platelets is released in the activation process. We analyzed the sCD40L serum concentration in cocaine users with acute coronary syndrome (ACS). Patients and methods: Retrospective comparison of sCD40L serum concentration between 40 patients with ACS and a positive test for cocaine in urine and 40 ACS patients with a negative cocaine test. Results: The mean (SD) sCD40L serum concentration in the patients with ACS and a negative cocaine test was lower (110 [41.1] pg/mL) than in patients who were not cocaine users (65.3 pg/mL) (P=.03). In the multivariable analysis, after adjustment for age and coronary risk in these patients with ACS, a positive cocaine test remained associated with sCD40L concentration. Conclusions: The sCD40L plays a part in the proinflammatory thrombotic process in cocaine users who develop ACS. [Emergencias 2011;23:104-107].

引用

页码：104 / 107

页数：4

共 50 条

[41] Soluble CD40 ligand in autoimmune diseases and atherosclerosis
Alexandrova, EN
Novikov, AA
Nasonov, EL
TERAPEVTICHESKII ARKHIV, 2005, 77 (12) : 91 - 95
[42] Soluble CD40 ligand levels in patients with hypertension
Sonmez, A
Dogru, T
Yilmaz, MI
Ocal, R
Ozgurtas, T
Kilic, S
Eyileten, T
Tasci, I
Erbil, K
Kocar, IH
CLINICAL AND EXPERIMENTAL HYPERTENSION, 2005, 27 (08) : 629 - 634
[43] Clopidogrel decreases soluble CD40 ligand in patients with stable coronary artery disease
Azar, RR
Kassab, R
Zoghbi, A
Aboujaoude, S
Ghorra, P
El-Osta, H
Germanos, M
Salame, E
CIRCULATION, 2005, 112 (17) : U544 - U544
[44] Short treatment with atorvastatin lowers platelet CD40 ligand expression and soluble CD40 ligand in hypercholesterolemic patients
Sanguigni, V
Pignatelli, P
Ferro, D
Bellia, A
Lenti, L
Tesauro, M
Lauro, R
Violi, F
EUROPEAN HEART JOURNAL, 2004, 25 : 49 - 50
[45] THE INFLUENCE OF CD40/CD40 LIGAND ON THE PROGNOSIS OF CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
Patiroglu, T.
Unal, E.
Karakukcu, M.
Mutlu, F. T.
Ozdemir, M. A.
HAEMATOLOGICA, 2012, 97 : 493 - 494
[46] Soluble CD40 ligand and outcome in patients with coronary artery disease undergoing percutaneous coronary intervention
Angeli, Fabio
Verdecchia, Paolo
Savonitto, Stefano
Cavallini, Sara
Santucci, Andrea
Coiro, Stefano
Sclafani, Rocco
Riccini, Clara
De Servi, Stefano
Cavallini, Claudio
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2022, 60 (01) : 118 - 126
[47] Association analysis of CD40 gene polymorphism with acute coronary syndrome
Jinchuan Yan
Cuiping Wang
Rongzeng Du
Peijin Liu
Guanghua Chen
Clinical and Experimental Medicine, 2010, 10 : 253 - 258
[48] Association analysis of CD40 gene polymorphism with acute coronary syndrome
Yan, Jinchuan
Wang, Cuiping
Du, Rongzeng
Liu, Peijin
Chen, Guanghua
CLINICAL AND EXPERIMENTAL MEDICINE, 2010, 10 (04) : 253 - 258
[49] Soluble CD40 as a modulator of CD40 pathway
Esposito, Pasquale
Rampino, Teresa
Dal Canton, Antonio
IMMUNOLOGY LETTERS, 2012, 147 (1-2) : 85 - 86
[50] Soluble CD40 ligand, platelet surface CD40 ligand, and total platelet CD40 ligand in atrial fibrillation - Relationship to soluble P-selectin, stroke risk factors, and risk factor intervention
Choudhury, Anirban
Chung, Irene
Panja, Nimai
Patel, Jeetesh
Lip, Gregory Y. H.
CHEST, 2008, 134 (03) : 574 - 581

← 1 2 3 4 5 →