Characterizing Emerging Canine H3 Influenza Viruses

被引：31

作者：

Martinez-Sobrido, Luis ^{[1
]}

Blanco-Lobo, Pilar ^{[1
]}

Rodriguez, Laura ^{[1
,29
]}

Fitzgerald, Theresa ^{[2
]}

Zhang, Hanyuan ^{[3
,4
]}

Phuong Nguyen ^{[2
]}

Anderson, Christopher S. ^{[2
]}

Holden-Wiltse, Jeanne ^{[5
]}

Bandyopadhyay, Sanjukta ^{[5
]}

Nogales, Aitor ^{[1
]}

DeDiego, Marta L. ^{[2
]}

Wasik, Brian R. ^{[6
]}

Miller, Benjamin L. ^{[3
,4
]}

Henry, Carole ^{[7
]}

Wilson, Patrick C. ^{[7
]}

Sangster, Mark Y. ^{[2
]}

Treanor, John J. ^{[2
]}

Topham, David J. ^{[2
]}

Byrd-Leotis, Lauren ^{[8
,9
,10
]}

Steinhauer, David A. ^{[8
]}

Cummings, Richard D. ^{[8
,9
,10
]}

Luczo, Jasmina M. ^{[11
]}

Tompkins, Stephen M. ^{[11
]}

Sakamoto, Kaori ^{[12
]}

Jones, Cheryl A. ^{[11
]}

Steel, John ^{[8
,30
]}

Lowen, Anice C. ^{[8
]}

Danzy, Shamika ^{[8
]}

Tao, Hui ^{[8
]}

Fink, Ashley L. ^{[13
]}

Klein, Sabra L. ^{[13
]}

Wohlgemuth, Nicholas ^{[13
]}

Fenstermacher, Katherine J. ^{[13
]}

el Najjar, Farah ^{[13
]}

Pekosz, Andrew ^{[13
]}

Sauer, Lauren ^{[14
]}

Lewis, Mitra K. ^{[14
]}

Shaw-Saliba, Kathryn ^{[14
]}

Rothman, Richard E. ^{[14
]}

Liu, Zhen-Ying ^{[15
]}

Chenid, Kuan-Fu ^{[15
]}

Parrish, Colin R. ^{[6
]}

Voorhees, Ian E. H. ^{[6
]}

Kawaoka, Yoshihiro ^{[16
]}

Neumann, Gabriele ^{[16
]}

Chiba, Shiho ^{[16
]}

Fan, Shufang ^{[16
]}

Hatta, Masato ^{[16
]}

Kong, Huihui ^{[16
]}

Zhong, Gongxun ^{[16
]}

机构：

[1] Univ Rochester, Dept Microbiol & Immunol, Rochester, NY 14642 USA

[2] Univ Rochester, David H Smith Ctr Vaccine Biol & Immunol, Rochester, NY USA

[3] Univ Rochester, Dept Dermatol, Rochester, NY 14627 USA

[4] Univ Rochester, Mat Sci Program, Rochester, NY USA

[5] Univ Rochester, Dept Biostat & Computat Biol, Rochester, NY USA

[6] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Baker Inst Anim Hlth, Ithaca, NY 14853 USA

[7] Univ Chicago, Dept Med, Sect Rheumatol, Knapp Ctr Lupus & Immunol Res, 5841 S Maryland Ave, Chicago, IL 60637 USA

[8] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA USA

[9] Harvard Med Sch, Dept Surg, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[10] Harvard Med Sch, Harvard Med Sch Ctr Glycosci, Boston, MA 02115 USA

[11] Univ Georgia, Ctr Vaccines & Immunol, Athens, GA 30602 USA

[12] Univ Georgia, Dept Pathol, Athens, GA USA

[13] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD USA

[14] Johns Hopkins Univ, Sch Med, Dept Emergency Med, Baltimore, MD USA

[15] Chang Gung Mem Hosp, Dept Emergency Med, Taoyuan, Taiwan

[16] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Influenza Res Inst, Madison, WI 53706 USA

[17] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[18] Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

[19] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY 10029 USA

[20] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA

[21] Univ Georgia, Dept Populat Hlth, Athens, GA 30602 USA

[22] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

[23] Univ Cambridge, Ctr Pathogen Evolut, Dept Zool, Cambridge, England

[24] St Jude Childrens Res Hosp, Dept Infect Dis, 332 N Lauderdale St, Memphis, TN 38105 USA

[25] Trop Hlth Fdn, Santa Marta, Magdalena, Colombia

[26] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Hong Kong, Peoples R China

[27] Duke NUS Med Sch, Programme Emerging Infect Dis, Singapore, Singapore

[28] St Jude Childrens Res Hosp, Dept Immunol, 332 N Lauderdale St, Memphis, TN 38105 USA

[29] Agencia Espanola Medicamentos & Prod Sanitarios, Madrid, Spain

[30] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA

来源：

PLOS PATHOGENS | 2020年 / 16卷 / 04期

基金：

美国国家卫生研究院;

关键词：

IN-VITRO CULTURES; AVIAN INFLUENZA; UNITED-STATES; A H5N1; ISOLATED WORLDWIDE; RAPID GENERATION; HOST RESPONSES; LINKED LECTIN; LABEL-FREE; EX-VIVO;

D O I：

10.1371/journal.ppat.1008409

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned. Author summary The 2009 influenza pandemic was a stark reminder that ongoing vigilance is critical to protect the public from an influenza pandemic. The continual evolution of influenza viruses and emergence from animal reservoirs, leads to the need to quickly identify strains that pose a public health risk. In these studies, members of the National Institutes of Allergy and Infectious Diseases (NIAID) Centers for Excellence in Influenza Research and Surveillance (CEIRS) network worked together to demonstrate that the emerging canine H3 influenza viruses posed a low risk to public health and identified several therapeutic options in the event of an emergence. In addition to providing important new basic research, many lessons were learned that may be important in dealing with any emerging disease outbreak.

引用

页数：34

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