A Placebo-Controlled Trial of Atomoxetine in Marijuana-Dependent Individuals with Attention Deficit Hyperactivity Disorder

被引：59
|
作者：
McRae-Clark, Aimee L. [1 ]
Carter, Rickey E. [2 ]
Killeen, Therese K. [1 ]
Carpenter, Matthew J. [1 ]
White, Kathleen G. [1 ]
Brady, Kathleen T. [1 ]
机构：
[1] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA
[2] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
来源：
AMERICAN JOURNAL ON ADDICTIONS | 2010年 / 19卷 / 06期
关键词：
DEFICIT/HYPERACTIVITY DISORDER; SUBSTANCE-ABUSE; ADULT ADHD; SUBTHRESHOLD DIAGNOSES; LATE-ONSET; FOLLOW-UP; ALCOHOL; METHYLPHENIDATE; COMORBIDITY; COGNITION;
D O I：
10.1111/j.1521-0391.2010.00076.x
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
This study evaluated the effects of atomoxetine on the symptoms of attention deficit hyperactivity disorder (ADHD) and marijuana use in marijuana-dependent adults. In conjunction with motivational interviewing, participants received either atomoxetine (n = 19) or matching placebo (n = 19) for 12 weeks. Participants randomized to atomoxetine had greater improvement in ADHD on the Clinical Global Impression-Improvement scale than participants treated with placebo. No treatment group differences in self-rated ADHD symptoms, overall Wender-Reimherr Adult Attention Deficit Disorder Scale scores, or marijuana use outcomes were noted. These results suggest that atomoxetine may improve some ADHD symptoms but does not reduce marijuana use in this population. (Am J Addict 2010;00:1-9).
引用
收藏
页码：481 / 489
页数：9
相关论文
共 50 条
  • [1] Efficacy of atomoxetine in placebo-controlled pediatric attention-deficit hyperactivity disorder trials
    Dunn, DW
    Wernicke, JF
    Faries, D
    Heiligenstein, JH
    Allen, AJ
    Laws, H
    Michelson, D
    ANNALS OF NEUROLOGY, 2001, 50 (03) : S96 - S96
  • [2] Safety of atomoxetine in placebo-controlled pediatric attention-deficit hyperactivity disorder trials
    Wernicke, JF
    Dunn, D
    Faries, DE
    Heiligenstein, JH
    Kelsey, DK
    Kendrick, KL
    Michelson, D
    ANNALS OF NEUROLOGY, 2001, 50 (03) : S123 - S124
  • [3] Efficacy of atomoxetine in placebo-controlled studies in children, adolescents, and adults with attention-deficit/hyperactivity disorder
    Simpson, A
    Kratochvil, CJ
    Newcorn, JH
    Allen, AJ
    Faries, D
    Milton, D
    Feldman, P
    Michelson, D
    Biederman, J
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2004, 7 : S441 - S441
  • [4] Efficacy of atomoxetine in placebo-controlled studies in children, adolescents, and adults with attention-deficit/hyperactivity disorder
    Simpson, A
    Kratochvil, C
    Spencer, TJ
    Buitelaar, JK
    Newcorn, JH
    Wilens, TE
    Allen, AJ
    Faries, DE
    Milton, DR
    Feldman, PD
    Michelson, D
    Biederman, J
    EUROPEAN PSYCHIATRY, 2004, 19 : 240S - 240S
  • [5] Dasotraline in adults with attention deficit hyperactivity disorder: a placebo-controlled, fixed-dose trial
    Adler, Lenard A.
    Goldman, Robert
    Hopkins, Seth C.
    Koblan, Kenneth S.
    Kent, Justine
    Hsu, Jay
    Loebel, Antony
    INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 2021, 36 (03) : 117 - 125
  • [6] A randomized, placebo-controlled trial of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder
    Biederman, J
    Mick, E
    Surman, C
    Doyle, R
    Hammerness, P
    Harpold, T
    Dunkel, S
    Dougherty, M
    Aleardi, M
    Spencer, T
    BIOLOGICAL PSYCHIATRY, 2006, 59 (09) : 829 - 835
  • [7] Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial
    Johnstone, Jeanette M.
    Hatsu, Irene
    Tost, Gabriella
    Srikanth, Priya
    Eiterman, Leanna P.
    Bruton, Alisha M.
    Ast, Hayleigh K.
    Robinette, Lisa M.
    Stern, Madeline M.
    Millington, Elizabeth G.
    Gracious, Barbara L.
    Hughes, Andrew J.
    Leung, Brenda M. Y.
    Arnold, L. Eugene
    JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2022, 61 (05): : 647 - 661
  • [8] Evaluation of Patients' and Parents' Quality of Life in a Randomized Placebo-Controlled Atomoxetine Study in Attention-Deficit/Hyperactivity Disorder
    Escobar, Rodrigo
    Montoya, Alonso
    Polavieja, Pepa
    Cardo, Esther
    Artigas, Josep
    Hervas, Amaia
    Fuentes, Joaquin
    JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 2009, 19 (03) : 253 - 263
  • [9] Efficacy of atomoxetine in adults with attention deficit hyperactivity disorder: An integrated analysis of the complete database of multicenter placebo-controlled trials
    Asherson, Philip
    Bushe, Chris
    Saylor, Keith
    Tanaka, Yoko
    Deberdt, Walter
    Upadhyaya, Himanshu
    JOURNAL OF PSYCHOPHARMACOLOGY, 2014, 28 (09) : 837 - 846
  • [10] Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder: A randomized, placebo-controlled study
    Michelson, D
    Allen, AJ
    Busner, J
    Casat, C
    Dunn, D
    Kratochvil, C
    Newcorn, J
    Sallee, FR
    Sangal, RB
    Saylor, K
    West, S
    Kelsey, D
    Wernicke, J
    Trapp, NJ
    Harder, D
    AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (11): : 1896 - 1901
12345