Wound-healing activity of an oligomer of alkannin/shikonin, isolated from root bark of Onosma echioides

被引：24

作者：

Nikita, Gawand ^{[1
]}

Vivek, Purnima ^{[1
]}

Chhaya, Gadgoli ^{[1
]}

机构：

[1] Saraswathi Vidya Bhavans Coll Pharm, Thana 421203, Maharashtra, India

来源：

NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 16期

关键词：

Onosma echioides; Boraginaceae; alkannin; shikonin oligomer; excision wound; incision wound; ALKANNA-TINCTORIA; SHIKONIN; CONSTITUENTS; CHEMISTRY; PIGMENTS; BIOLOGY;

D O I：

10.1080/14786419.2014.986126

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Root bark of Onosma echioides belonging to the family Boraginaceae is reported to be rich in naphthaquinones such as alkannins and shikonins. In this study, a dimer of alkannin/shikonin was isolated from the petroleum ether (60-80C) extract of the bark, and the structure of the same was elucidated through spectral studies (UV, IR, NMR, MS and DEPT). The petroleum ether extract was found to contain 62.4% (w/w) of the dimer of alkannin/shikonin, and the compound is found to promote wound-healing process, when studied in the excision and incision wound models in albino rats.

引用

页码：1584 / 1588

页数：5

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