Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses

被引：82

作者：

Monteleone, Giovanni ^{[1
,2
]}

Pallone, Francesco ^{[1
,2
]}

MacDonald, Thomas T. ^{[3
]}

机构：

[1] Univ Roma Tor Vergata, Dipartimento Med Interna, I-00133 Rome, Italy

[2] Univ Roma Tor Vergata, Ctr Eccellenza Studio Malattie Complesse & Multif, I-00133 Rome, Italy

[3] Barts & London Queen Marys Sch Med & Dent, Inst Cell & Mol Sci, London E1 2AT, England

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 06期

关键词：

D O I：

10.1016/j.it.2008.02.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Naive T cells can commit to effector [T helper 1 (Th1), Th2 and Th17] or regulatory lineages. Skewing of responses toward inflammatory Th1, Th2 or Th17 pathways and away from regulatory T-cell pathways might be responsible for the initiation and progress of immune-mediated diseases. Based on recent data, we propose that interleukin-21 (IL-21), a cytokine produced by activated CD4(+) T cells, induces the development of Th17 cells, blocks the differentiation of transforming growth factor-beta 1-induced regulatory T cells and renders CD4(+) T cells resistant to the suppressive effects of regulatory T cells, thereby playing a major role in pathogenic T-cell responses.

引用

页码：290 / 294

页数：5

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