Stem cells for Parkinson disease and ALS: replacement or protection?

被引:60
|
作者
Svendsen, CN [1 ]
Langston, JW
机构
[1] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA
[2] Parkinsons Inst, Sunnyvale, CA 94089 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nm0304-224
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Using stem cells to generate new neurons and replace those lost in diseases such as Parkinson and amyotrophic lateral sclerosis would be a major breakthrough, but significant hurdles remain before this goal can be realized. Instead, a more practical short-term approach may be to use stem cells to protect neurons dying in these diseases.
引用
收藏
页码:224 / 225
页数:2
相关论文
共 50 条
  • [21] Advancing Parkinson's disease treatment: cell replacement therapy with neurons derived from pluripotent stem cells
    Clark, Branden J.
    Lelos, Mariah J.
    Loring, Jeanne F.
    STEM CELLS, 2024, 42 (09) : 781 - 790
  • [22] Cell Replacement Therapy for Parkinson's Disease with Neuronal Cells Derived from Human Parthernogenetic Stem Cell
    Garitaonandia, Ibon
    Gonzalez, Rodolfo
    Ostrowska, Alina
    Abramihina, Tatiana
    Wambua, Gerald
    Noskov, Alexander
    Boscolo, Francesca
    Laurent, Louise
    Redmond, Eugene
    Snyder, Evan
    Semechkin, Ruslan
    MOLECULAR THERAPY, 2013, 21 : S178 - S179
  • [23] Stem Cells in Amyotrophic Lateral Sclerosis: Motor Neuron Protection or Replacement?
    Silani, V.
    Calzarossa, C.
    Cova, L.
    Ticozzi, N.
    CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2010, 9 (03) : 314 - 324
  • [24] Stem Cells as In Vitro Model of Parkinson's Disease
    Martinez-Morales, Patricia L.
    Liste, Isabel
    STEM CELLS INTERNATIONAL, 2012, 2012
  • [25] Stem Cells for Modeling and Therapy of Parkinson's Disease
    Zhang, Qingxi
    Chen, Wanling
    Tan, Sheng
    Lin, Tongxiang
    HUMAN GENE THERAPY, 2017, 28 (01) : 85 - 98
  • [26] Stem cells and regenerative therapies for Parkinson's disease
    Farrell, Krista
    Barker, Roger A.
    DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE, 2012, 2 : 79 - 92
  • [27] Is treatment with stem cells effective in Parkinson's disease?
    Rocco, Matias
    Juri, Carlos
    MEDWAVE, 2018, 18 (05):
  • [28] Translational Research on Stem Cells for Parkinson's Disease
    Parker, Graham C.
    STEM CELLS AND DEVELOPMENT, 2018, 27 (14) : 949 - 950
  • [29] Transplantation of embryonic stem cells in Parkinson's disease
    May, TS
    LANCET NEUROLOGY, 2002, 1 (01): : 6 - 6
  • [30] Role of Neural Stem Cells in Parkinson's Disease
    Millan-Guerrero, Rebeca
    CURRENT SIGNAL TRANSDUCTION THERAPY, 2011, 6 (03) : 337 - 340