Ovarian cancer: new developments in clear cell carcinoma and hopes for targeted therapy

被引：15
|
作者：
Yamashita, Yoriko [1 ]
机构：
[1] Nagoya City Univ, Grad Sch Med Sci, Dept Expt Pathol & Tumor Biol, Nagoya, Aichi 4678601, Japan
来源：
JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2015年 / 45卷 / 05期
基金：
日本学术振兴会;
关键词：
ovarian clear cell carcinoma; PI3CA mutation; ARID1A mutation; MET amplification; targeted therapy; MALIGNANT-TRANSFORMATION; HISTOLOGICAL SUBTYPES; TUMOR-SUPPRESSOR; PIK3CA GENE; ENDOMETRIOSIS; GROWTH; EXPRESSION; MUTATIONS; ARID1A; CARCINOGENESIS;
D O I：
10.1093/jjco/hyu221
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Until recently, ovarian clear cell carcinoma was recognized by its unique morphology and unfavorable patient outcome primarily due to tumor chemoresistance. Recently, specific molecular characteristics of ovarian clear cell carcinoma, such as PI3CA mutation, ARID1a mutation and MET amplification, have been elucidated. In addition, an association between endometriosis and the tumor has also been a focus of research in recent years. The aim of this review is to discuss the specificity and importance of molecular changes and various intriguing points that are not solved until today. Finally, future aspects, including hopes for the development of novel therapies, are discussed.
引用
收藏
页码：405 / 407
页数：3
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