Organocatalytic Combinatorial Synthesis of Quinazoline, Quinoxaline and Bis(indolyl)methanes

被引：2

作者：

Malamiri, Fatemeh ^{[1
]}

Khaksar, Samad ^{[2
,3
]}

Badri, Rashid ^{[4
]}

Tahanpesar, Elham ^{[4
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Khouzestan Sci & Res Branch, Ahvaz, Iran

[2] Islamic Azad Univ, Dept Chem, Ayatollah Amoli Branch, Amol, Iran

[3] Univ Georgia, Sch Sci & Technol, Tbilisi, Georgia

[4] Islamic Azad Univ, Dept Chem, Ahvaz Branch, Ahvaz, Iran

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2020年 / 23卷 / 01期

关键词：

Organocatalyst; green chemistry; quinazoline; multicomponent; heterocyclic; anticancer; ONE-POT SYNTHESIS; HIGHLY EFFICIENT; PENTAFLUOROPHENYLAMMONIUM TRIFLATE; RAPID SYNTHESIS; CATALYST; ACID; DERIVATIVES; CHEMOTHERAPY; PROTECTION; CHEMISTRY;

D O I：

10.2174/1386207323666191213123026

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Aims and Objective: An efficient and practical procedure for the synthesis of heterocyclic compounds such as quinazolines, quinoxalines and bis(indolyl)methanes was developed using 3,5-bis(trifluoromethyl) phenyl ammonium hexafluorophosphate (BFPHP) as a novel organocatalyst. Materials and Methods: All of the obtained products are known compounds and identified by IR, (HNMR)-H-1, (CNMR)-C-13 and melting points. Result: Various products were obtained in good to excellent yields under reaction conditions Conclusion: The BFPHP organocatalyst demonstrates a novel class of non-asymmetric organocatalysts, which has gained much attention in green chemistry.

引用

页码：83 / 88

页数：6

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