Role of autophagy in metabolic syndrome-associated heart disease

被引:52
|
作者
Ren, Sidney Y. [1 ]
Xu, Xihui [1 ]
机构
[1] Univ Wyoming, Coll Hlth Sci, Sch Pharm, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2015年 / 1852卷 / 02期
关键词
Autophagy; Heart; Metabolic syndrome; High fat diet; Obesity; INDUCED CARDIAC-HYPERTROPHY; DIET-INDUCED OBESITY; 3RD NATIONAL-HEALTH; INSULIN-RESISTANCE; CONTRACTILE DYSFUNCTION; CARDIOVASCULAR-DISEASE; MOLECULAR-MECHANISMS; MYOCARDIAL-ISCHEMIA; DIASTOLIC FUNCTION; PROVISIONAL REPORT;
D O I
10.1016/j.bbadis.2014.04.029
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metabolic syndrome is a constellation of multiple metabolic risk factors including abdominal obesity, glucose intolerance, insulin resistance, dyslipidemia and hypertension. Over the past decades, the prevalence of metabolic syndrome has increased dramatically, imposing a devastating, pandemic health threat More importantly, individuals with metabolic syndrome are at an increased risk of diabetes mellitus and overall cardiovascular diseases. One of the common comorbidities of metabolic syndrome is heart anomalies leading to the loss of cardiomyocytes, cardiac dysfunction and ultimately heart failure. Up-to-date, a plethora of cell signaling pathways have been postulated for the pathogenesis of cardiac complications in obesity including lipotoxicity, inflammation, oxidative stress, apoptosis and sympathetic overactivation although the precise mechanism of action underscoring obesity-associated heart dysfunction remains elusive. Recent evidence has indicated a potential role of protein quality control in components of metabolic syndrome. Within the protein quality control system, the autophagy-lysosome pathway is an evolutionarily conserved pathway responsible for bulk degradation of large intracellular organelles and protein aggregates. Autophagy has been demonstrated to play an indispensible role in the maintenance of cardiac geometry and function under both physiological and pathological conditions. Accumulating studies have demonstrated that autophagy plays a pivotal role in the etiology of cardiac anomalies under obesity and metabolic syndrome. In this minireview, we will discuss on how autophagy is involved in the regulation of cardiac function in obesity and metabolic syndrome. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:225 / 231
页数:7
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