A femtosecond laser inscribed biochip for stem cell therapeutic applications

被引：0
|
作者：
Choudhury, D. [1 ]
Ramsay, W. T. [1 ]
Brown, G. [1 ]
Psaila, N. D. [1 ]
Beecher, S. [1 ]
Thomson, R. R. [1 ]
Kiss, R. [2 ]
Pells, S. [3 ]
Willoughby, N. A. [2 ]
Paterson, L. [1 ]
Kar, A. K. [1 ]
机构：
[1] Heriot Watt Univ, Dept Phys, SUPA, Sch Engn & Phys Sci, David Brewster Bldg, Edinburgh EH14 4AS, Midlothian, Scotland
[2] Heriot Watt Univ, Sch Engn & Phys Sci, Dept Chem Engn, Edinburgh EH14 4AS, Midlothian, Scotland
[3] Univ Edinburgh, MRC Ctr Regenerat Med, Edinburgh EH16 4SB, Midlothian, Scotland
来源：
MICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS IX | 2011年 / 7929卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
femtosecond laser inscription; chemical etching; cell separation; cell sorting; fused silica; human embryonic stem cells; SEPARATION; EXPRESSION; CHIP;
D O I：
10.1117/12.874954
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A continuous flow microfluidic cell separation platform has been designed and fabricated using femtosecond laser inscription. The device is a scalable and non-invasive cell separation mechanism aimed at separating human embryonic stem cells from differentiated cells based on the dissimilarities in their cytoskeletal elasticity. Successful demonstration of the device has been achieved using human leukemia cells the elasticity of which is similar to that of human embryonic stem cells.
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页数：6
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