Perspective: Dynamics of receptor tyrosine kinase signaling complexes

被引：24

作者：

Mayer, Bruce J. ^{[1
,2
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Raymond & Beverly Sackler Lab Genet & Mol Med, Dept Genet & Dev Biol, Farmington, CT 06030 USA

[2] Univ Connecticut, Ctr Hlth, Richard Berlin Ctr Cell Anal & Modeling, Farmington, CT 06030 USA

来源：

FEBS LETTERS | 2012年 / 586卷 / 17期

基金：

美国国家卫生研究院;

关键词：

Receptor tyrosine kinase; SH2; domain; Signal transduction; V-CRK ONCOGENE; INTERACTION DOMAINS; PHOSPHOLIPASE-C; BINDING-SITE; SH2; DOMAIN; PHOSPHOTYROSINE; PROTEINS; GRB2; PHOSPHOPEPTIDES; TRANSFORMATION;

D O I：

10.1016/j.febslet.2012.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Textbook descriptions of signal transduction complexes provide a static snapshot view of highly dynamic events. Despite enormous strides in identifying the key components of signaling complexes and the underlying mechanisms of signal transduction, our understanding of the dynamic behavior of these complexes has lagged behind. Using the example of receptor tyrosine kinases, this perspective takes a fresh look at the dynamics of the system and their potential impact on signal processing. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2575 / 2579

页数：5

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