Perspective: Dynamics of receptor tyrosine kinase signaling complexes

被引：24
|
作者：
Mayer, Bruce J. [1 ,2 ]
机构：
[1] Univ Connecticut, Ctr Hlth, Raymond & Beverly Sackler Lab Genet & Mol Med, Dept Genet & Dev Biol, Farmington, CT 06030 USA
[2] Univ Connecticut, Ctr Hlth, Richard Berlin Ctr Cell Anal & Modeling, Farmington, CT 06030 USA
来源：
FEBS LETTERS | 2012年 / 586卷 / 17期
基金：
美国国家卫生研究院;
关键词：
Receptor tyrosine kinase; SH2; domain; Signal transduction; V-CRK ONCOGENE; INTERACTION DOMAINS; PHOSPHOLIPASE-C; BINDING-SITE; SH2; DOMAIN; PHOSPHOTYROSINE; PROTEINS; GRB2; PHOSPHOPEPTIDES; TRANSFORMATION;
D O I：
10.1016/j.febslet.2012.05.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Textbook descriptions of signal transduction complexes provide a static snapshot view of highly dynamic events. Despite enormous strides in identifying the key components of signaling complexes and the underlying mechanisms of signal transduction, our understanding of the dynamic behavior of these complexes has lagged behind. Using the example of receptor tyrosine kinases, this perspective takes a fresh look at the dynamics of the system and their potential impact on signal processing. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2575 / 2579
页数：5
相关论文
共 50 条
  • [1] Receptor tyrosine kinase signaling - a proteomic perspective
    Biarc, Jordane
    Chalkley, Robert J.
    Burlingame, A. L.
    Bradshaw, Ralph A.
    ADVANCES IN ENZYME REGULATION, VOL 51, 2011, 51 : 293 - 305
  • [2] NEW INSIGHTS INTO PROTEIN-TYROSINE KINASE RECEPTOR SIGNALING COMPLEXES
    FRY, MJ
    PANAYOTOU, G
    BOOKER, GW
    WATERFIELD, MD
    PROTEIN SCIENCE, 1993, 2 (11) : 1785 - 1797
  • [3] Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics
    Kiyatkin, Anatoly
    van Rosenburgh, Iris K. van Alderwerelt
    Klein, Daryl E.
    Lemmon, Mark A.
    SCIENCE SIGNALING, 2020, 13 (645)
  • [4] Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases
    Östman, A
    Böhmer, FD
    TRENDS IN CELL BIOLOGY, 2001, 11 (06) : 258 - 266
  • [5] Receptor tyrosine kinase signaling in vascular development
    Merenmies, J
    Parada, LF
    Henkemeyer, M
    CELL GROWTH & DIFFERENTIATION, 1997, 8 (01): : 3 - 10
  • [6] Ligand bias in receptor tyrosine kinase signaling
    Karl, Kelly
    Paul, Michael D.
    Pasquale, Elena B.
    Hristova, Kalina
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295 (52) : 18494 - 18507
  • [7] Accounting for specificity in receptor tyrosine kinase signaling
    Madhani, HD
    CELL, 2001, 106 (01) : 9 - 11
  • [8] Quantification of receptor tyrosine kinase signaling.
    Kholodenko, BN
    Hoek, JB
    FASEB JOURNAL, 2000, 14 (08): : A1314 - A1314
  • [9] MenaINV dysregulation of receptor tyrosine kinase signaling
    Oudin, Madeleine J.
    Hughes-Alford, Shannon K.
    Miller, Miles
    Asokan, Sreeja B.
    Bear, James E.
    Lauffenburger, Doug A.
    Gertier, Frank B.
    CANCER RESEARCH, 2013, 73
  • [10] Importance of tyrosine phosphorylation in receptor kinase complexes
    Macho, Alberto P.
    Lozano-Duran, Rosa
    Zipfel, Cyril
    TRENDS IN PLANT SCIENCE, 2015, 20 (05) : 269 - 272
12345