Serum and plasma concentration of oxidant and antioxidants in patients of Helicobacter pylori gastritis and its correlation with gastric cancer

被引：49
|
作者：
Khanzode, SS
Khanzode, SD
Dakhale, GN
机构：
[1] Govt Med Coll, Dept Med, Nagpur 440022, Maharashtra, India
[2] Govt Med Coll, Dept Pharmacol, Nagpur 440022, Maharashtra, India
来源：
CANCER LETTERS | 2003年 / 195卷 / 01期
关键词：
Helicobacter pylori gastritis; gastric carcinoma; superoxide dismutase; plasma ascorbic acid; malondialdehyde;
D O I：
10.1016/S0304-3835(03)00147-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Serum superoxide dismutase, plasma ascorbic acid and lipid peroxidation in H. pylori gastritis and gastric cancer patients were compared with values for age matched healthy subjects. Serum superoxide dismutase and serum malondialdehyde were analyzed spectrophotometrically whereas plasma ascorbic acid was determined by colorimetric method. Significant increase in serum superoxide dismutase and serum malondialdehyde and significant decrease in plasma ascorbic acid were observed in H. pylori gastritis and gastric cancer patients compared to control subjects. The concentration of serum superoxide dismutase and serum malondialdehyde was significantly higher and plasma ascorbic acid was significantly lower in gastric cancer as compared to H. pylori gastritis patients. Our results demonstrate that a correlation existed between the concentration of serum superoxide dismutase, plasma ascorbic acid and lipid peroxidation in H. pylori gastritis and gastric cancer patients. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：27 / 31
页数：5
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