Antifungal Activity of Flavonoid Isolated from Lindernia crustacea (L) F. Muell against Traditionally Claimed Dermatophytes

被引：1
|
作者：
Das, Smriti Rekha Chanda [1 ]
Ahmed, Abdul Baquee [1 ]
Shil, Dibyendu [2 ]
Das, Trishna [1 ]
Alam, Faruk [3 ]
Chakraborty, Jashabir [2 ]
机构：
[1] Girijananda Chowdhury Inst Pharmaceut Sci, Dept Pharmaceut Chem, Gauhati 781017, Assam, India
[2] Mata Gujri Univ, Mata Gujri Coll Pharm, Dept Pharmacognosy, Purabpali Rd, Kishanganj 855107, Bihar, India
[3] Assam Down Town Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem, Gauhati 781026, Assam, India
来源：
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL | 2021年 / 33卷 / 46B期
关键词：
Lindernia crustacea (L) F; benzene extract; isolation; flavonoid; antifungal activity; ANTIMICROBIAL ACTIVITY; EXTRACTS;
D O I：
10.9734/JPRI/2021/v33i46B32970
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: The present study was aimed to establish antifungal activity of flavonoid isolated from Lindernia crustacea (L) F. Muell. Methods: Potent bioactive constituent from benzene extract was isolated through flash chromatography with solvent Toluene and Acetic acid (4:1). Isolated compound was structurally established by spectroscopic method. Antifungal potential of benzene extract as well as isolated compound was tested by disc diffusion method against two fungal strains Candida albicans (C. albicans) and Trichophyton rubrum (T. rubrum). Results: The isolated compound from benzene extract was found to be flavonoid. Benzene extract as well as flavonoid were shown remarkable zone of inhibition against both fungal strains which indicates strong antifungal activity. Conclusion: The experimental results concluded that Lindernia crustacea (L) F. Muell have significant anti fungal activity due to flavonoid content. It is expected that the results of the present research work would be beneficial in establishing the scientific basis of the traditional claims of medicinal values of Lindernia crustacea.
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收藏
页码：512 / 521
页数：10
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