Cucurbitane-type triterpenoids from the fruit of Momordica charantia

被引：54
|
作者：
Kimura, Y
Akihisa, T
Yuasa, N
Ukiya, M
Suzuki, T
Toriyama, M
Motohashi, S
Tokuda, H
机构：
[1] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, Tokyo 1018308, Japan
[2] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan
[3] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 05期
关键词：
D O I：
10.1021/np040218p
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The structures of three new cucurbitane-type triterpenoids isolated from the methanol extract of the fruit of Japanese Momordica charantia were established as (19R,23E)-5 beta, 19-epoxy- 19-methoxycucurbita-6,23,25-trien-3 beta-ol (1), (23E)-3 beta-hydroxy-7 beta-methoxycucurbita-5,23,25-trien-19-al (2), and (23E)-3 beta-hydroxy-7 beta,25-dimethoxycueurbita-5,23-dien-19-al (3) on the basis of spectroscopic methods. These compounds were accompanied by the known (19R,23E)-5 beta,19-epoxy-19,25-dimethoxycueurbita-6,23-dien-3 beta-ol (4) and (19R,23E)-5 beta,19-epoxy-19-methoxycucurbita-6,23-diene-3 beta,25-diol (5). This is the first report of the isolation of tetracyclic triterpenoids possessing a Delta(23,25)-conjugated diene system, viz., 1 and 2, from a natural source.
引用
收藏
页码：807 / 809
页数：3
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