Long-term results of permanent implant prostate cancer brachytherapy: A single-institution study of 675 patients treated between 1999 and 2003

被引:2
|
作者
Cosset, J. -M. [1 ,6 ]
Flam, T. [1 ,2 ]
Belin, L. [1 ]
Thiounn, N. [3 ]
Pierrat, N. [1 ]
Pontvert, D. [1 ]
Wakil, G. [1 ,4 ]
Savignoni, A. [1 ]
Chauveinc, L. [1 ,5 ]
机构
[1] Inst Curie, 26 Rue Ulm, F-75005 Paris, France
[2] Fdn St Jean de Dieu Oudinot, 19 Rue Oudinot, F-75007 Paris, France
[3] Hop Europeen Georges Pompidou, 20 Rue Leblanc, F-75015 Paris, France
[4] Charles Lemoyne Hosp, 3120 Blvd Taschereau,Greenfield Pk, Montreal, PQ J4V 2H1, Canada
[5] Ctr Radiotherapie Hartmann, 4 Rue Kleber, F-93200 Levallois Perret, France
[6] Ctr Radiotherapie Charlebourg La Def, Grp Amethyst, 65 Ave Foch, F-92250 La Garenne Colombes, France
来源
CANCER RADIOTHERAPIE | 2016年 / 20卷 / 04期
关键词
Prostate cancer; Brachytherapy; Permanent implant; Toxicity; DOSE-RESPONSE ANALYSIS; QUALITY-OF-LIFE; INTERSTITIAL BRACHYTHERAPY; I-125; MONOTHERAPY; ERECTILE FUNCTION; SEED BRACHYTHERAPY; RECTAL FUNCTION; FOLLOW-UP; OUTCOMES; EXPERIENCE;
D O I
10.1016/j.canrad.2016.02.009
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose. - To analyse long-term overall survival, relapse-free survival and late toxicities in a series of 675 patients treated between 1999 and 2003, with a median follow-up of 132 months. Patients and methods. - The cohort included low-risk patients and a selection of "favourable-intermediate" risk patients. All patients were homogeneously treated using an intraoperative dynamic planning prostate brachytherapy technique, with loose 125 iodine seeds. Hormone therapy, consisting most often of an anti-androgen alone, was given in 393 patients (58%). Results. - The 10-year overall survival was 92% (95% confidence interval [CI]: 90-94) without a significant difference between the low and the select intermediate-risk groups (P=0.17). The 10-year relapse-free survival rate for the entire cohort was 82% (95% CI: 79-85), and was significantly higher in the low-risk group than in the intermediate one (87 vs 71%; P<0.0001). Twenty-six percent of the relapses observed in this series occurred after more than 10 years of follow-up. The 10-year cumulative incidence of grade 3-4 urinary toxicity (whatever the delay and the recovery) was 5.78%. The cumulative incidence of grades 3-4 rectal toxicity in the present series was 1.65% at 10 years. As for sexual toxicity, 61% of our patients retained an erectile capacity at 10 years (with or without oral medication), with age being a major factor. Conclusion. - With a median follow-up of more than 11 years, this series appears to confirm the excellent long-term results of low-dose rate prostate brachytherapy, both in terms of survival and in terms of toxicity. (C) 2016 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:261 / 267
页数:7
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