Synthesis of the C1-C20 and C15-C27 Segments of Aplyronine A

被引：18
|
作者：
Hong, Wan Pyo [1 ]
Noshi, Mohammad N. [1 ]
El-Awa, Ahmad [1 ]
Fuchs, Philip L. [1 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 24期
关键词：
POTENT ANTITUMOR SUBSTANCE; MARINE MACROLIDE SYNTHESIS; ORGANIC-SYNTHESIS; STEREOCONTROLLED SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ALDEHYDES; CONVERSION; SULFONES; ORIGIN; STEREOTETRADS;
D O I：
10.1021/ol2024746
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of C1-C20 and C15-C27 segments of Aplyronine A is described. Oxidative cleavage of cyclic vinyl sulfones has been used to prepare key fragments of Aplyronine A. Key precursors are united by Horner-Wadsworth-Emmons and Julia-Kociensky olefination for the respective elaboration of the C1-C20 and C15-C27 segments.
引用
收藏
页码：6342 / 6345
页数：4
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