The Importance of Senescence in Ionizing Radiation-Induced Tumour Suppression

被引：0
|
作者：
Vavrova, J. [1 ]
Rezacova, M. [2 ]
机构：
[1] Univ Def Brno, Fac Mil Hlth Sci Hradec Kralove, Dept Radiobiol, Hradec Kralove 50001, Czech Republic
[2] Charles Univ Prague, Fac Med Hradec Kralove, Dept Med Biochem, Hradec Kralove, Czech Republic
来源：
FOLIA BIOLOGICA | 2011年 / 57卷 / 02期
关键词：
review; senescence; ionizing radiation; cytokine expression; ONCOGENE-INDUCED SENESCENCE; DNA-DAMAGE CHECKPOINT; BETA-GALACTOSIDASE; HUMAN-CELLS; P53; PHOSPHORYLATION; ACTIVATION; ATM; IRRADIATION; BIOMARKER;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cellular senescence is a condition of long-lasting proliferation arrest, induced in cells in response to various stressors. These stressors include telomere shortening and/or dysfunction, DNA damage, and oncogene signalling. Epithelial and mesenchymal cells and also tumour cells derived from these tissues are more resistant to radiation-induced apoptosis and respond to irradiation mainly by senescence. Senescence-associated molecular mechanisms related to the activation of canonical DNA damage pathway ATM-p53 as well as mechanisms related to the extracellular signals, cytokine increase and up-regulation of their receptors are discussed in this review.
引用
收藏
页码：41 / 46
页数：6
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