Innate recognition of non-self nucleic acids

被引：26

作者：

Chi, Hongbo ^{[3
]}

Flavell, Richard A. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[3] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

GENOME BIOLOGY | 2008年 / 9卷 / 03期

关键词：

D O I：

10.1186/gb-2008-9-3-211

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The immune system has evolved a plethora of innate receptors that detect microbial DNA and RNA, including Toll-like receptors in the endosomal compartment and RIG-I-like receptors and Nod-like receptors in the cytosol. Here we discuss the recognition of and responses to non-self nucleic acids via these receptors as well as their involvement in autoimmune diseases.

引用

页数：7

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