Alcohol consumption and the risk of mortality and myocardial infarction in patients with rheumatoid arthritis

被引:0
|
作者
Smith, I. D. [1 ,2 ,5 ]
Lu, N. [3 ,4 ]
Wei, J. [3 ,4 ]
Zhang, Y. [3 ,4 ]
Choi, H. K. [3 ,4 ]
Bolster, M. B. [3 ,4 ]
机构
[1] Duke Univ, Duke Univ Hosp, Dept Med, Sch Med, Durham, NC USA
[2] Duke Univ, Duke Univ Hosp, Div Rheumatol & Immunol, Sch Med, Durham, NC USA
[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Boston, MA USA
[4] Harvard Med Sch, Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Boston, MA USA
[5] Duke Univ Hosp, Div Rheumatol & Immunol, 2301 Erwin Rd, Durham, NC 27710 USA
关键词
rheumatoid arthritis; alcohol drinking; mortality; myocardial infarction; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; ADIPONECTIN; METAANALYSIS; EVENTS; WOMEN; PROTEIN; ADULTS; LIPIDS; ROLES;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
ObjectiveMany studies have found that moderate alcohol consumption is associated with lower risks of mortality and myocardial infarction (MI). Our aim was to examine the potential effects of alcohol on all-cause mortality and MI in rheumatoid arthritis (RA), a risk factor condition.MethodsA cohort study (1995-2017) was conducted using medical records of RA patients from The Health Improvement Network in the United Kingdom (UK). Alcohol exposure was divided into non-drinkers, mild (1-7 UK units/week), moderate (8-14 UK units/week), moderate-high (15-21 UK units/week), and high (>21 UK units/week) consumption levels. We calculated hazard ratios (HRs) for the relation of alcohol consumption to all-cause mortality and MI, adjusting for covariates.ResultsOf 30,320 RA patients, 5,994 deaths and 1,098 MI cases occurred over 236,188 person-years. Mild-to-moderate alcohol use was associated with lower all-cause mortality in RA patients, including those taking methotrexate. The multivariable HRs (95% CI) for mortality by alcohol use category were non-drinkers 1.0, mild 0.80 (0.75-0.85), moderate 0.74 (0.67-0.82), moderate-high 0.84 (0.72-0.98), and high 0.99 (0.86-1.15). Mild, moderate-high, and high levels of alcohol use were associated with lower risk of MI among RA patients. The HRs MI risk by alcohol use category were non-drinkers 1.0, mild 0.81 (0.70-0.94), moderate 0.84 (0.68-1.04), moderate-high 0.51 (0.35-0.74), and high 0.59 (0.42-0.84).ConclusionThese findings suggest that mild-to-moderate alcohol use is associated with a lower mortality risk and overall alcohol use is associated with a lower MI risk in RA patients, similar to the general population.
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页码:1754 / 1761
页数:8
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