Extensive Methylation of SFFV Promoter Sequences Does Not Allow Lentiviral Transgene Expression In Vivo

被引：0
|
作者：
Herbst, Friederike [1 ,2 ]
Ball, Claudia R. [1 ,2 ]
Tuorto, Francesca [2 ]
Wang, Wei [2 ]
Kloz, Ulrich [2 ]
van der Hoeven, Franciscus [2 ]
Lyko, Frank [2 ]
Schmidt, Manfred [1 ,2 ]
von Kalle, Christof [1 ,2 ]
Glimm, Hanno [1 ,2 ]
机构：
[1] Natl Ctr Tumour Dis NCT, Heidelberg, Germany
[2] German Canc Res Ctr, Heidelberg, Germany
来源：
HUMAN GENE THERAPY | 2010年 / 21卷 / 09期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
引用
收藏
页码：1203 / 1203
页数：1
相关论文
共 50 条
  • [1] Impaired Lentiviral Transgene Expression In Vivo Caused by Massive Methylation of SFFV Promoter Sequences
    Herbst, Friederike
    Ball, Claudia R.
    Tuorto, Francesca
    Wang, Wei
    Kloz, Ulrich
    van der Hoeven, Frank
    Lyko, Frank
    Von Kalle, Christof
    Glimm, Hanno
    BLOOD, 2010, 116 (21) : 1541 - 1541
  • [2] Highly methylated SFFV promoter sequences prevent lentiviral transgene expression in vivo
    Herbst, F.
    Ball, C. R.
    Tuorto, F.
    Wang, W.
    van der Hoeven, F.
    Kloz, U.
    Lyko, F.
    Schmidt, M.
    von Kalle, C.
    Glimm, H.
    ONKOLOGIE, 2011, 34 : 261 - 261
  • [3] Extensive Methylation of Promoter Sequences Silences Lentiviral Transgene Expression During Stem Cell Differentiation In Vivo
    Herbst, Friederike
    Ball, Claudia R.
    Tuorto, Francesca
    Nowrouzi, Ali
    Wang, Wei
    Zavidij, Oksana
    Dieter, Sebastian M.
    Fessler, Sylvia
    van der Hoeven, Franciscus
    Kloz, Ulrich
    Lyko, Frank
    Schmidt, Manfred
    von Kalle, Christof
    Glimm, Hanno
    MOLECULAR THERAPY, 2012, 20 (05) : 1014 - 1021
  • [4] Was cDNA Sequences Modulate Transgene Expression of Was Promoter-Driven Lentiviral Vectors
    Toscano, Miguel G.
    Benabdellah, Karim
    Munoz, Pilar
    Frecha, Cecilia
    Cobo, Marien
    Martin, Francisco
    HUMAN GENE THERAPY, 2009, 20 (11) : 1279 - 1290
  • [5] Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo
    Philippe, Stephanie
    Sarkis, Chamsy
    Barkats, Martine
    Mammeri, Hamid
    Ladroue, Charline
    Petit, Caroline
    Mallet, Jacques
    Serguera, Che
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (47) : 17684 - 17689
  • [6] Wasp cDNA Sequences Modulate Transgene Expression of Was Promoter-Driven Lentiviral Vectors
    Munoz, Pilar
    Toscano, Miguel G.
    Benabdellah, Karim
    Frecha, Cecilia
    Cobo, Marien
    Martin, Francisco
    HUMAN GENE THERAPY, 2009, 20 (09) : 1051 - 1052
  • [7] High Transgene Expression by Lentiviral Vectors Causes Maldevelopment of Purkinje Cells In Vivo
    Yusuke Sawada
    Go Kajiwara
    Akira Iizuka
    Kiyohiko Takayama
    Anton N. Shuvaev
    Chiho Koyama
    Hirokazu Hirai
    The Cerebellum, 2010, 9 : 291 - 302
  • [8] High Transgene Expression by Lentiviral Vectors Causes Maldevelopment of Purkinje Cells In Vivo
    Sawada, Yusuke
    Kajiwara, Go
    Iizuka, Akira
    Takayama, Kiyohiko
    Shuvaev, Anton N.
    Koyama, Chiho
    Hirai, Hirokazu
    CEREBELLUM, 2010, 9 (03): : 291 - 302
  • [9] Transgenic pigs for xenotransplantation: selection of promoter sequences for reliable transgene expression
    Aigner, Bernhard
    Klymiuk, Nikolai
    Wolf, Eckhard
    CURRENT OPINION IN ORGAN TRANSPLANTATION, 2010, 15 (02) : 201 - 206
  • [10] Baroreceptor reflex stimulation does not induce cytomegalovirus promoter-driven transgene expression in the ventrolateral medulla in vivo
    Allen, Andrew M.
    Dosanjh, Jaspreet
    Dassanayake, Sashikala
    Tan, Geraldine
    Thomas, Walter G.
    AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2006, 126 : 150 - 155
12345