Muscle oxygenation of the paralyzed lower limb in spinal cord-injured persons

Purpose: Even in the paralyzed lower limb muscle, EMG activity can be induced by imposing passive leg movement in standing posture in persons with spinal cord injury (SCI). The purpose of the present study was to ascertain whether the oxygenation level of the paralyzed lower limb muscle covaried with the muscle EMG activity during imposed passive leg movement. Methods: Six motor-complete SCI subjects and four neurologically normal controls were placed on a gait-training apparatus that enabled the SCI subjects to stand and move their legs passively. After a 1-min resting stage, consecutive passive alternate leg movements were performed at different frequencies (0.8, 1, 1.2, and I Hz, for 3 min at each stage). To obtain postexercise data, subjects were kept in a standing posture for 5 min after passive movement ceased. The EMG activity and concentration changes in the oxygenated (oxy-) and deoxygenated hemoglobin (Hb) (deoxy-Hb) were continuously measured using near-infrared spectroscopy (NIRS) from the gastrocnemius muscle. Results: In all SCI subjects, muscle EMG activity was observed during passive leg movement. The oxy-Hb level gradually increased, whereas the deoxy-Hb decreased, and these changes were independent of the total Hb changes. In the recovery stage, the total Hb level was found to exceed the preexercise level. In contrast to the SCI patients, the normal subjects showed neither EMG activity nor changes in oxy- or deoxy-Hb. Conclusion: The present results demonstrate that passive leg movement can induce not only muscular activity but also alteration of muscle oxygenation level in the paralyzed lower leg. Particularly, induced muscular activity seems to correlate with increased perfusion of the muscle.