The interpretative field on Newton's work has been widely discussed and, particularly, the subject of hypotheses has not been the exception. The aim of this paper is to show that the natural philosophy of Newton seemed, in principle, to reject the hypothesis, but it is not opposed to the formulation of these if we distinguish what kind of hypothesis we mean. Thus, I will show, first, how Newton develops its natural philosophy, and how he opposed to the hypotheses. Then I will show that under certain conditions the hypotheses are accepted. And therefore, I conclude that the philosophy of Newton not radically rejects the hypothesis, but, on the contrary, he may use them for the scientific development, depending on what type of hypothesis is referred.