The genetics and biochemistry of resistance to glycopeptide antibiotics - Glycopeptide resistance mechanisms

被引：0
|
作者：
Reynolds, PE [1 ]
机构：
[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England
来源：
NOVEL FRONTIERS IN THE PRODUCTION OF COMPOUNDS FOR BIOMEDICAL USE, VOL 1 | 2001年 / 1卷
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D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Enterococci and staphylococci have evolved different resistance mechanisms to counteract glycopeptide antibiotics. High- and low-level resistance in enterococci results from new pathways of peptidoglycan biosynthesis together with elimination of peptidoglycan precursors with high affinity for glycopeptides. In staphylococci the main mechanism appears to involve sequestration of the antibiotic in the outer layers of the cell wall before it reaches the vital target sites.
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页码：99 / 115
页数：17
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