Deep-learning synthesized pseudo-CT for MR high-resolution pediatric cranial bone imaging (MR-HiPCB)
被引:9
|
作者:
Boroojeni, Parna Eshraghi
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机构:
Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USAWashington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
Boroojeni, Parna Eshraghi
[1
]
Chen, Yasheng
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机构:
Washington Univ, Dept Neurol, St Louis, MO 63110 USAWashington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
Chen, Yasheng
[2
]
Commean, Paul K.
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机构:
Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USAWashington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
Commean, Paul K.
[3
]
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Eldeniz, Cihat
[3
]
Skolnick, Gary B.
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机构:
Washington Univ, Div Plast & Reconstruct Surg, St Louis, MO 63110 USAWashington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
Skolnick, Gary B.
[4
]
Merrill, Corinne
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机构:
Washington Univ, Div Plast & Reconstruct Surg, St Louis, MO 63110 USAWashington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
Merrill, Corinne
[4
]
Patel, Kamlesh B.
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机构:
Washington Univ, Div Plast & Reconstruct Surg, St Louis, MO 63110 USAWashington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
Patel, Kamlesh B.
[4
]
An, Hongyu
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机构:
Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
Washington Univ, Dept Neurol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USAWashington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
An, Hongyu
[1
,2
,3
]
机构:
[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
[2] Washington Univ, Dept Neurol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA
[4] Washington Univ, Div Plast & Reconstruct Surg, St Louis, MO 63110 USA
cranial bone imaging;
craniosynostosis;
deep learning;
head trauma;
MRI;
pseudo-CT;
TRAUMATIC BRAIN-INJURY;
ATTENUATION CORRECTION;
COMPUTED-TOMOGRAPHY;
BLACK BONE;
RADIATION-EXPOSURE;
3-DIMENSIONAL RECONSTRUCTION;
CRANIOFACIAL SKELETON;
CHILDREN;
SEGMENTATION;
PET/MRI;
D O I:
10.1002/mrm.29356
中图分类号:
R8 [特种医学];
R445 [影像诊断学];
学科分类号:
1002 ;
100207 ;
1009 ;
摘要:
Purpose CT is routinely used to detect cranial abnormalities in pediatric patients with head trauma or craniosynostosis. This study aimed to develop a deep learning method to synthesize pseudo-CT (pCT) images for MR high-resolution pediatric cranial bone imaging to eliminating ionizing radiation from CT. Methods 3D golden-angle stack-of-stars MRI were obtained from 44 pediatric participants. Two patch-based residual UNets were trained using paired MR and CT patches randomly selected from the whole head (NetWH) or in the vicinity of bone, fractures/sutures, or air (NetBA) to synthesize pCT. A third residual UNet was trained to generate a binary brain mask using only MRI. The pCT images from NetWH (pCT(NetWH)) in the brain area and NetBA (pCT(NetBA)) in the nonbrain area were combined to generate pCT(Com). A manual processing method using inverted MR images was also employed for comparison. Results pCT(Com) (68.01 +/- 14.83 HU) had significantly smaller mean absolute errors (MAEs) than pCT(NetWH) (82.58 +/- 16.98 HU, P < 0.0001) and pCT(NetBA) (91.32 +/- 17.2 HU, P < 0.0001) in the whole head. Within cranial bone, the MAE of pCT(Com) (227.92 +/- 46.88 HU) was significantly lower than pCT(NetWH) (287.85 +/- 59.46 HU, P < 0.0001) but similar to pCT(NetBA) (230.20 +/- 46.17 HU). Dice similarity coefficient of the segmented bone was significantly higher in pCT(Com) (0.90 +/- 0.02) than in pCT(NetWH) (0.86 +/- 0.04, P < 0.0001), pCT(NetBA) (0.88 +/- 0.03, P < 0.0001), and inverted MR (0.71 +/- 0.09, P < 0.0001). Dice similarity coefficient from pCT(Com) demonstrated significantly reduced age dependence than inverted MRI. Furthermore, pCT(Com) provided excellent suture and fracture visibility comparable to CT. Conclusion MR high-resolution pediatric cranial bone imaging may facilitate the clinical translation of a radiation-free MR cranial bone imaging method for pediatric patients.
机构:
Washington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USAWashington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USA
Linkugel, Andrew D.
Wang, Tongyao
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机构:
Washington Univ, Mallinckrodt Inst Radiol, St Louis, MO 63110 USAWashington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USA
Wang, Tongyao
Boroojeni, Parna Eshraghi
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机构:
Washington Univ, Mallinckrodt Inst Radiol, St Louis, MO 63110 USAWashington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USA
Boroojeni, Parna Eshraghi
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机构:
Eldeniz, Cihat
Chen, Yasheng
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Dept Neurol, St Louis, MO 63110 USAWashington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USA
Chen, Yasheng
Skolnick, Gary B.
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h-index: 0
机构:
Washington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USAWashington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USA
Skolnick, Gary B.
Commean, Paul K.
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h-index: 0
机构:
Washington Univ, Mallinckrodt Inst Radiol, St Louis, MO 63110 USAWashington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USA
Commean, Paul K.
Merrill, Corinne M.
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机构:
Washington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USAWashington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USA
Merrill, Corinne M.
Strahle, Jennifer M.
论文数: 0引用数: 0
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机构:
Washington Univ, Dept Neurosurg, St Louis, MO 63110 USAWashington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USA
Strahle, Jennifer M.
Goyal, Manu S.
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Washington Univ, Mallinckrodt Inst Radiol, St Louis, MO 63110 USAWashington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USA
Goyal, Manu S.
An, Hongyu
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机构:
Washington Univ, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA
Washington Univ, Dept Neurol, St Louis, MO 63110 USAWashington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USA
An, Hongyu
Patel, Kamlesh B.
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机构:
Washington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USAWashington Univ, Div Plast & Reconstruct Surg, 660 South Euclid Ave,Campus Box 8238, St. Louis, MO 63110 USA
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Harvard Med Sch, Charlestown, MA USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Torrado-Carvajal, Angel
Vera-Olmos, Javier
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Univ Rey Juan Carlos, Med Image Anal & Biometry Lab, Madrid, SpainMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Vera-Olmos, Javier
Izquierdo-Garcia, David
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Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Harvard Med Sch, Charlestown, MA USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Izquierdo-Garcia, David
Catalano, Onofrio A.
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Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Harvard Med Sch, Charlestown, MA USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Catalano, Onofrio A.
Morales, Manuel A.
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机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Harvard Med Sch, Charlestown, MA USA
MIT, Dept Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Morales, Manuel A.
Margolin, Justin
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Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Harvard Med Sch, Charlestown, MA USA
Northeastern Univ, Boston, MA 02115 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Margolin, Justin
Soricelli, Andrea
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机构:
IRCCS, SDN Ist Ric Diagnost & Nucl, Naples, Italy
Univ Naples Parthenope, Dept Motor Sci & Wellness, Naples, ItalyMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Soricelli, Andrea
Salvatore, Marco
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IRCCS, SDN Ist Ric Diagnost & Nucl, Naples, ItalyMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Salvatore, Marco
Malpica, Norberto
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Univ Rey Juan Carlos, Med Image Anal & Biometry Lab, Madrid, SpainMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Malpica, Norberto
Catana, Ciprian
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Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
Harvard Med Sch, Charlestown, MA USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
机构:
Univ N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
Univ N Carolina, BRIC, CB 7513, Chapel Hill, NC 27510 USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
Chen, Yong
Fang, Zhenghan
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Univ N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
Univ N Carolina, BRIC, CB 7513, Chapel Hill, NC 27510 USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
Fang, Zhenghan
Hung, Sheng-Che
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Univ N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
Univ N Carolina, BRIC, CB 7513, Chapel Hill, NC 27510 USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
Hung, Sheng-Che
Chang, Wei-Tang
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Univ N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
Univ N Carolina, BRIC, CB 7513, Chapel Hill, NC 27510 USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
Chang, Wei-Tang
Shen, Dinggang
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Univ N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
Univ N Carolina, BRIC, CB 7513, Chapel Hill, NC 27510 USA
Korea Univ, Dept Brain & Cognit Engn, Seoul 02841, South KoreaUniv N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
Shen, Dinggang
Lin, Weili
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Univ N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
Univ N Carolina, BRIC, CB 7513, Chapel Hill, NC 27510 USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27515 USA
机构:
Hong Kong Sanat & Hosp, Med Phys & Res Dept, Hong Kong, Peoples R ChinaHong Kong Sanat & Hosp, Med Phys & Res Dept, Hong Kong, Peoples R China
Law, M.
Yuan, J.
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Hong Kong Sanat & Hosp, Med Phys & Res Dept, Hong Kong, Peoples R ChinaHong Kong Sanat & Hosp, Med Phys & Res Dept, Hong Kong, Peoples R China
Yuan, J.
Lo, G.
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Hong Kong Sanat & Hosp, Dept Diagnost & Intervent Radiol, Hong Kong, Peoples R ChinaHong Kong Sanat & Hosp, Med Phys & Res Dept, Hong Kong, Peoples R China
Lo, G.
Wong, O.
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Hong Kong Sanat & Hosp, Med Phys & Res Dept, Hong Kong, Peoples R ChinaHong Kong Sanat & Hosp, Med Phys & Res Dept, Hong Kong, Peoples R China
Wong, O.
Zhou, Y.
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Hong Kong Sanat & Hosp, Med Phys & Res Dept, Hong Kong, Peoples R ChinaHong Kong Sanat & Hosp, Med Phys & Res Dept, Hong Kong, Peoples R China
Zhou, Y.
Yu, S.
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Hong Kong Sanat & Hosp, Med Phys & Res Dept, Hong Kong, Peoples R ChinaHong Kong Sanat & Hosp, Med Phys & Res Dept, Hong Kong, Peoples R China
机构:
Johns Hopkins Univ Hosp, Russell H Morgan Dept Radiol & Radiol Sci, 600 North Wolfe St, Baltimore, MD 21287 USAJohns Hopkins Univ Hosp, Russell H Morgan Dept Radiol & Radiol Sci, 600 North Wolfe St, Baltimore, MD 21287 USA
Wen, Jessica
Desai, Naman S.
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机构:
Johns Hopkins Univ Hosp, Div Neuroradiol, Russell H Morgan Dept Radiol & Radiol Sci, Phipps B-100,600 North Wolfe St, Baltimore, MD 21287 USAJohns Hopkins Univ Hosp, Russell H Morgan Dept Radiol & Radiol Sci, 600 North Wolfe St, Baltimore, MD 21287 USA
Desai, Naman S.
Jeffery, Dean
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Johns Hopkins Univ Hosp, Div Neuroradiol, Russell H Morgan Dept Radiol & Radiol Sci, Phipps B-100,600 North Wolfe St, Baltimore, MD 21287 USAJohns Hopkins Univ Hosp, Russell H Morgan Dept Radiol & Radiol Sci, 600 North Wolfe St, Baltimore, MD 21287 USA
Jeffery, Dean
Aygun, Nafi
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Johns Hopkins Univ Hosp, Div Neuroradiol, Russell H Morgan Dept Radiol & Radiol Sci, Phipps B-100,600 North Wolfe St, Baltimore, MD 21287 USAJohns Hopkins Univ Hosp, Russell H Morgan Dept Radiol & Radiol Sci, 600 North Wolfe St, Baltimore, MD 21287 USA
Aygun, Nafi
Blitz, Ari
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Johns Hopkins Univ Hosp, Div Neuroradiol, Russell H Morgan Dept Radiol & Radiol Sci, Phipps B-100,600 North Wolfe St, Baltimore, MD 21287 USAJohns Hopkins Univ Hosp, Russell H Morgan Dept Radiol & Radiol Sci, 600 North Wolfe St, Baltimore, MD 21287 USA