Synthesis of some new 2-[2,6,8-trisubstituted-4(3H)-oxoquinazolin-3-yl]-5-aryl-1,3,4-thiadiazoles as potential antinflammatory agents

Twelve new 2-[2,6,8-trisubstituted-4 (3H)-oxoquinazolin-3-yl]-5-aryl-1,3,4-thiadiazoles (9-20) were synthesized by reacting different aromatic carboxylic acids with corresponding 2,6,8-trisubstituted-3-thiosemicarbazido -4 (3H)-quinazolones (5-8). These thiosemicarbazido -4(3H)-quinazolones, on the other hand, were obtained by the condensation of 3-amino-2,6,8-trisubstitued -4(3H)-quinazolones (1-4) with carbon disulfide ammonia and hydrazine hydrate. All these intermediate compounds and the title compounds were characterized by their analytical and spectral data. Many of the title compounds were found to be good antiinflammatory agents on evaluation.