Opportunities and Challenges for Nanotherapeutics for the Aging Population

被引：9

作者：

Hunt, Nicholas J. ^{[1
,2
,3
,4
,5
]}

McCourt, Peter A. G. ^{[4
,6
]}

Kuncic, Zdenka ^{[5
,7
]}

Le Couteur, David G. ^{[1
,2
,3
,4
]}

Cogger, Victoria C. ^{[1
,2
,3
,4
]}

机构：

[1] ANZAC Res Inst, Ageing & Alzheimers Inst, Concord, NSW, Australia

[2] Concord Repatriat Gen Hosp, Ctr Educ & Res Ageing, Concord, NSW, Australia

[3] Univ Sydney, Fac Med & Hlth, Camperdown, NSW, Australia

[4] Univ Sydney, Charles Perkins Ctr, Camperdown, NSW, Australia

[5] Univ Sydney, Sydney Nano Inst, Camperdown, NSW, Australia

[6] Univ Tromso, Arctic Univ Norway, Dept Med Biol, Tromso, Norway

[7] Univ Sydney, Sch Phys, Sydney, NSW, Australia

来源：

FRONTIERS IN NANOTECHNOLOGY | 2022年 / 4卷

基金：

芬兰科学院; 欧盟地平线“2020”; 澳大利亚国家健康与医学研究理事会;

关键词：

drug delivery and targeting; ADME and toxicity; nano; ageing; clinical challenges; quantum dot; solid lipid nanoparticle; pharmaceuical; SINUSOIDAL ENDOTHELIAL-CELLS; RECEPTOR-MEDIATED ENDOCYTOSIS; DRUG-METABOLIZING-ENZYMES; MOLECULAR-WEIGHT HEPARIN; ORAL DELIVERY; GOLD NANOPARTICLES; DEOXYCHOLIC-ACID; NICOTINAMIDE MONONUCLEOTIDE; INTESTINAL MICROBIOTA; LIPID NANOPARTICLES;

D O I：

10.3389/fnano.2022.832524

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Nanotherapeutics utilize the properties of nanomaterials to alter the pharmacology of the drugs and therapies being transported, leading to changes in their biological disposition (absorption, distribution, cellular uptake, metabolism and elimination) and ultimately, their pharmacological effect. This provides an opportunity to optimize the pharmacology of drugs, particularly for those that are dependent on hepatic action. Old age is associated with changes in many pharmacokinetic processes which tend to impair drug efficacy and increase risk of toxicity. While these age-related changes are drug-specific they could be directly addressed using nanotechnology and precision targeting. The benefits of nanotherapeutics needs to be balanced against toxicity, with future use in humans dependent upon the gathering of information about the clearance and long-term safety of nanomaterials.

引用

页数：15

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