FASPAD:: fast signaling pathway detection

被引：12
|
作者：
Hueffner, Falk [1 ]
Wernicke, Sebastian [1 ]
Zichner, Thomas [1 ]
机构：
[1] Univ Jena, Inst Informat, D-07743 Jena, Germany
来源：
BIOINFORMATICS | 2007年 / 23卷 / 13期
关键词：
D O I：
10.1093/bioinformatics/btm160
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
FASPAD is a user-friendly tool that detects candidates for linear signaling pathways in protein interaction networks based on an approach by Scott et al. ( Journal of Computational Biology, 2006). Using recent algorithmic insights, it can solve the underlying NP-hard problem quite fast: for protein networks of typical size ( several thousand nodes), pathway candidates of length up to 13 proteins can be found within seconds and with a 99.9% probability of optimality. FASPAD graphically displays all candidates that are found; for evaluation and comparison purposes, an overlay of several candidates and the surrounding network context can also be shown.
引用
收藏
页码：1708 / 1709
页数：2
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