Metalated Aziridines for Cross-Coupling with Aryl and Alkenyl Halides via Palladium Catalysis

被引：13
|
作者：
Nelson, John M. [1 ]
Vedejs, Edwin [1 ]
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 22期
基金：
美国国家卫生研究院;
关键词：
LITHIATION; ANALOGS; SERINE;
D O I：
10.1021/ol101904a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The palladium-catalyzed coupling of an aziridinylzinc chloride intermediate with alkenyl and aryl halides has been demonstrated. The method provides products with retention of aziridine stereochemistry. The utility of the coupling procedure is illustrated in the synthesis of structures related to L-furanomycin.
引用
收藏
页码：5085 / 5087
页数：3
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