Clinical impact of the clone size in MDS cases with monosomy 7 or 7q deletion, trisomy 8, 20q deletion and loss of Y chromosome

被引：10
|
作者：
Mallo, Mar [1 ,2 ]
Luno, Elisa
Sanzo, Carmen
Cervera, Jose
Haase, Detlef
Schanze, Julie
Garcia-Manero, Guillermo [3 ]
del Canizo, Consuelo
Sanz, Guillermo F.
Sole, Francesc [1 ]
机构：
[1] Hosp Mar, GRETNHE, IMIM, Mol Cytogenet Lab,Dept Pathol,Res Inst, Barcelona 08003, Spain
[2] Autonomous Univ Barcelona, Fac Life Sci, Dept Cell Biol Physiol & Immunol, Bellaterra, Spain
[3] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA
来源：
LEUKEMIA RESEARCH | 2011年 / 35卷 / 06期
关键词：
Myelodysplastic syndrome; Cytogenetic; Clone burden; INSIGHTS;
D O I：
10.1016/j.leukres.2011.01.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The clone size has been postulated as a prognostic factor in myelodysplastic syndromes (MDS), though it has not been studied systematically. We tested its impact (< 100% vs. 100%) in a population of 216 MDS with chromosome 7 abnormalities (-7/7q-) (n = 84), trisomy 8 (n = 99), 20q deletion (n = 28) and loss of Y chromosome (n = 26). Focusing on the survival the bad prognosis of -7/7q- was independent of the clone size (9.3 vs. 5.0 months, P = 0.188, not significant) but trisomy 8 cases with 100% aberrant metaphases did reveal a worse prognosis (13.9 vs. 5.9 months, P = 0.003). (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：834 / 836
页数：3
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