Recent Developments in the Synthesis of Chiral Compounds with Quaternary Centers by Organocatalytic Cascade Reactions

被引：76

作者：

Tian, Li ^{[1
]}

Luo, Yong-Chun ^{[1
]}

Hu, Xiu-Qin ^{[1
]}

Xu, Peng-Fei ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 05期

关键词：

aminocatalysis; catalytic cascade reactions; hydrogen-bonding catalysis; ion-pairing catalysis; quaternary centers; DIELS-ALDER REACTION; ASYMMETRIC STRECKER REACTION; 4 CONTIGUOUS STEREOCENTERS; PHASE-TRANSFER CATALYSIS; MICHAEL-MICHAEL CASCADE; ENANTIOSELECTIVE CONSTRUCTION; DOMINO REACTIONS; ALPHA; BETA-UNSATURATED KETONES; SPIROOXINDOLE DERIVATIVES; ORGANOCASCADE CATALYSIS;

D O I：

10.1002/ajoc.201500486

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quaternary carbon stereocenters are present in a wide variety of organic compounds and drug molecules. Highly enantioselective construction of such quaternary carbon stereocenters has received considerable attention owing to the great challenges in their syntheses. With the development of asymmetric organocatalytic cascade reactions, several efficient methods for the construction of optically pure compounds with quaternary carbon centers have been developed. This focused review highlights the asymmetric synthesis of chiral compounds with quaternary centers through organocatalytic cascade reactions.

引用

页码：580 / 607

页数：28

共 50 条

[41] Recent developments in antimicrobial small molecule quaternary phosphonium compounds (QPCs) - synthesis and biological insights
Mcdonough, Diana
Sanchez, Christian A.
Wuest, William M.
Minbiole, Kevin P. C.
RSC MEDICINAL CHEMISTRY, 2025, 16 (03): : 1000 - 1022
[42] Chiral separations: Recent developments in chiral stationary phases and chromatographic separations of chiral compounds
Trapp, Oliver
Berova, Nina
Collina, Simona
Pescitelli, Gennaro
CHIRALITY, 2024, 36 (03)
[43] Electrochemical cascade reactions: an account of recent developments for this modern strategic tool in the arsenal of chemical synthesis
Yadav, Manoj Kumar
Chowdhury, Sushobhan
GREEN CHEMISTRY, 2023, 25 (24) : 10144 - 10181
[44] Cascade reactions in total synthesis - Recent advances
Nicolaou, KC
Snyder, SA
ACTUALITE CHIMIQUE, 2003, (4-5): : 83 - 88
[45] Organocatalytic Stereoselective Synthesis of Acyclic γ-Nitrothioesters with All-Carbon Quaternary Stereogenic Centers
Arakawa, Yukihiro
Fritz, Sven P.
Wennemers, Helma
JOURNAL OF ORGANIC CHEMISTRY, 2014, 79 (09): : 3937 - 3945
[46] Recent advances in organocatalytic asymmetric oxa-Michael addition triggered cascade reactions
Wang, Yu
Du, Da-Ming
ORGANIC CHEMISTRY FRONTIERS, 2020, 7 (20) : 3266 - 3283
[47] Two Competitive but Switchable Organocatalytic Cascade Reaction Pathways: The Diversified Synthesis of Chiral Acetal-Containing Bridged Cyclic Compounds
Lv, Xue-Jiao
Chen, Ying-Han
Liu, Yan-Kai
ORGANIC LETTERS, 2019, 21 (01) : 190 - 195
[48] Organocatalytic asymmetric synthesis of chiral oxindoles bearing a quaternary center at the 3-position
Noole, Artur
Kanger, Tonis
Malkov, Andrei V.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
[49] Recent developments in the synthesis and catalytic applications of chiral phosphetanes
Marinetti, A
Genêt, JP
COMPTES RENDUS CHIMIE, 2003, 6 (04) : 507 - 514
[50] All-carbon chiral quaternary centers via asymmetric hydrovinylation: Enantioselective synthesis of (-)-desoxyeseroline and related compounds
RajanBabu, T. V.
Lim, Hwan Jung
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238

← 1 2 3 4 5 →