A Polybasic Patch on Synaptotagmin-1 C2A Domain is Essential for Evoked Release and Dilation of Fusion Pores

被引:0
|
作者
Wu, Zhenyong [1 ]
Ma, Lu [2 ]
Zhu, Jie [1 ]
Courtney, Nicholas [3 ]
Zhang, Yongli [2 ]
Chapman, Edwin R. [3 ,4 ]
Karatekin, Erdem [1 ]
机构
[1] Yale Univ, Cellular & Mol Physiol, New Haven, CT USA
[2] Yale Univ, Cell Biol, New Haven, CT USA
[3] Univ Wisconsin, Neurosci, Madison, WI USA
[4] HHMI, Chevy Chase, MD USA
关键词
D O I
暂无
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
1962-Pos
引用
收藏
页码:400A / 400A
页数:1
相关论文
共 44 条
  • [31] Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release
    Voleti, Rashmi
    Tomchick, Diana R.
    Sudhof, Thomas C.
    Rizo, Josep
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (40) : E8518 - E8527
  • [32] Triggering Fusion and Expanding the Fusion Pore: Dual Roles for the Second C2 Domain of Synaptotagmin 1
    Nyenhuis, Sarah B.
    Karandikar, Nakul
    Kiessling, Volker
    Kreutzberger, Alex J. B.
    Thapa, Anusa
    Liang, Binyong
    Tamm, Lukas K.
    Cafiso, David S.
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 50A - 50A
  • [33] Ca2+ Regulates the Drosophila Stoned-A and Stoned-B Proteins Interaction with the C2B Domain of Synaptotagmin-1
    Soekmadji, Carolina
    Angkawidjaja, Clement
    Kelly, Leonard E.
    PLOS ONE, 2012, 7 (06):
  • [34] C2A domain of synaptotagmin-7 as regulator of fusion pore expansion during the post-fusion stage of lamellar body exocytosis in alveolar type II epithelial cells
    Neuland, K.
    Sharma, N.
    Timmler, M.
    Miklavc, P.
    Wittekindt, O. H.
    Dietl, P.
    Frick, M.
    ACTA PHYSIOLOGICA, 2014, 210 : 98 - 98
  • [35] NMR T1/HSQC measurements of electrostatically modulated nitroxide accessibility to the backbone amide protons of synaptotagmin I C2A domain
    Bhowmik, A
    Ellena, JE
    Fanucci, GE
    Frazier, AA
    Bryant, RG
    Cafiso, DS
    BIOPHYSICAL JOURNAL, 2004, 86 (01) : 255A - 255A
  • [36] Copper binding affinity of the C2B domain of synaptotagmin-1 and its potential role in the nonclassical secretion of acidic fibroblast growth factor
    Jayanthi, Srinivas
    Kathir, Karuppanan Muthusamy
    Rajalingam, Dakshinamurthy
    Furr, Mercede
    Daily, Anna
    Thurman, Ryan
    Rutherford, Lindsay
    Chandrashekar, Reena
    Adams, Paul
    Prudovsky, Igor
    Kumar, Thallapuranam Krishnaswamy Suresh
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2014, 1844 (12): : 2155 - 2163
  • [37] synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo
    Littleton, JT
    Bai, JH
    Vyas, B
    Desai, R
    Baltus, AE
    Garment, MB
    Carlson, SD
    Ganetzky, B
    Chapman, ER
    JOURNAL OF NEUROSCIENCE, 2001, 21 (05): : 1421 - 1433
  • [38] Role of the C2B domain of synaptotagmin 1 in spontaneous neurotransmitter release from mouse hippocampal neurons
    Nishiki, Tei-ichi
    Ohmori, Ion
    Tomizawa, Kazuhito
    Matsui, Hideki
    Augustine, George
    NEUROSCIENCE RESEARCH, 2008, 61 : S216 - S216
  • [39] Dissociation of inositol polyphosphates from the C2B domain of synaptotagmin facilitates spontaneous release of catecholamines in adrenal chromaffin cells. A suggestive evidence of a fusion clamp by synaptotagmin
    Sasakawa, Nobuyuki
    Ohara-Imaizumi, Mica
    Fukuda, Mitsunori
    Kabayama, Hiroyuki
    Mikoshiba, Katsuhiko
    Kumakura, Konosuke
    NEUROPHARMACOLOGY, 2011, 60 (7-8) : 1364 - 1370
  • [40] Hydrophobic Contributions to the Membrane Docking of Synaptotagmin 7 C2A Domain: Mechanistic Contrast between Isoforms 1 and 7 (vol 51, pg 7654, 2012)
    Brandt, Devin S.
    Coffman, Matthew D.
    Falke, Joseph J.
    Knight, Jefferson D.
    BIOCHEMISTRY, 2013, 52 (09) : 1649 - 1649