Effect of aortic valve replacement on plasma soluble P-selectin, von Willebrand factor, and fibrinogen

被引：17
|
作者：
Goldsmith, IRA
Blann, AD
Patel, RL
Lip, GYH
机构：
[1] Univ Birmingham, Dept Med, City Hosp, Haemostasis Thrombosis & Vasc Biol Unit, Birmingham B18 7QH, W Midlands, England
[2] Walsgrave Gen Hosp, Dept Cardiothorac Surg, Coventry, W Midlands, England
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 87卷 / 01期
关键词：
D O I：
10.1016/S0002-9149(00)01283-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We measured indexes of platelet activation (soluble P-selectin), endothelial dysfunction (von Willebrand factor), and fibrinogen in 54 patients who underwent aortic valve replacement (AVR): after mechanical AVR implantation, there was a significant increase in plasma levels of soluble P-selectin and von Willebrand factor levels 3 months after surgery, with no change in mean plasma fibrinogen levels. No significant changes in measured indexes were noted in patients undergoing biologic AVR, suggesting that mechanical AVR results in abnormal endothelial damage and/or dysfunction and platelet activation, which is not apparent among patients undergoing this procedure.
引用
收藏
页码：107 / +
页数：5
相关论文
共 50 条
  • [21] Effects of congestive heart failure on plasma von Willebrand factor and soluble P-selectin concentrations in patients with non-valvar atrial fibrillation
    Lip, GYH
    Pearce, LA
    Chin, BSP
    Conway, DSG
    Hart, RG
    HEART, 2005, 91 (06) : 759 - 763
  • [22] Soluble CD40 ligand, soluble P-selectin and von Willebrand factor levels in subjects with prediabetes: The impact of metabolic syndrome
    Genc, Halil
    Dogru, Teoman
    Tapan, Serkan
    Tasci, Ilker
    Bozoglu, Ergun
    Gok, Mahmut
    Aslan, Fatih
    Celebi, Gurkan
    Erdem, Gokhan
    Avcu, Ferit
    Ural, Ali Ugur
    Sonmez, Alper
    CLINICAL BIOCHEMISTRY, 2012, 45 (1-2) : 92 - 95
  • [23] Clinical significance of platelet P-selectin and von Willebrand factor in unstable angina pectoris
    Ueno, A
    Murasaki, K
    Yamauchi, T
    Tsurumi, Y
    Kawaguchi, M
    Uetsuka, Y
    Kawana, M
    Kasanuki, H
    Ohki, K
    Akamatsu, N
    Tanoue, K
    THROMBOSIS AND HAEMOSTASIS, 1999, : 657 - 657
  • [24] Endothelial von Willebrand factor and P-selectin co-localize in ventilation stress
    Yiming, MT
    Bhattacharya, S
    FASEB JOURNAL, 2004, 18 (04): : A328 - A328
  • [25] Inverse relationship between plasma von Willebrand factor and soluble P selectin in patients with type 1 but not type 2 von Willebrand disease
    Blann, AD
    Nitu-Whalley, IC
    Lee, CA
    Lip, GYH
    AMERICAN JOURNAL OF HEMATOLOGY, 2002, 69 (02) : 135 - 137
  • [26] High levels of platelet-monocyte aggregates after valve replacement for aortic stenosis: Relation to soluble P-selectin and P-selectin glycoprotein ligand-1 genes
    Eslam, Roza Badr
    Gremmel, Thomas
    Schneller, Alexandra
    Stegfellner, Michael
    Kaider, Alexandra
    Mannhalter, Christine
    Lang, Irene
    Panzer, Simon
    THROMBOSIS RESEARCH, 2012, 129 (04) : 453 - 458
  • [27] Prognostic value of plasma von Willebrand factor and soluble P-selectin as indices of endothelial damage and platelet activation in 994 patients with nonvalvular atrial fibrillation
    Conway, DSG
    Pearce, LA
    Chin, BSP
    Hart, RG
    Lip, GYH
    CIRCULATION, 2003, 107 (25) : 3141 - 3145
  • [28] The levels of soluble P-selectin, von Willebrand factor and thrombomodulin in patients with neurological complications after allogeneic bone marrow transplantation
    H Takatsuka
    Y Takemoto
    T Okamoto
    Y Fujimori
    A Suehiro
    E Kakishita
    A Kanamaru
    Bone Marrow Transplantation, 1998, 21 : 809 - 813
  • [29] Von Willebrand Factor Multimers during Transcatheter Aortic-Valve Replacement
    Van Belle, E.
    Rauch, A.
    Vincent, F.
    Robin, E.
    Kibler, M.
    Labreuche, J.
    Jeanpierre, E.
    Levade, M.
    Hurt, C.
    Rousse, N.
    Dally, J. -B.
    Debry, N.
    Dallongeville, J.
    Vincentelli, A.
    Delhaye, C.
    Auffray, J. -L.
    Juthier, F.
    Schurtz, G.
    Lemesle, G.
    Caspar, T.
    Morel, O.
    Dumonteil, N.
    Duhamel, A.
    Paris, C.
    Dupont-Prado, A.
    Legendre, P.
    Mouquet, F.
    Marchant, B.
    Hermoire, S.
    Corseaux, D.
    Moussa, K.
    Manchuelle, A.
    Bauchart, J. -J.
    Loobuyck, V.
    Caron, C.
    Zawadzki, C.
    Leroy, F.
    Bodart, J. -C.
    Staels, B.
    Goudemand, J.
    Lenting, P. J.
    Susen, S.
    NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (04): : 335 - 344
  • [30] The levels of soluble P-selectin, von Willebrand factor and thrombomodulin in patients with neurological complications after allogeneic bone marrow transplantation
    Takatsuka, H
    Takemoto, Y
    Okamoto, T
    Fujimori, Y
    Suehiro, A
    Kakishita, E
    Kanamaru, A
    BONE MARROW TRANSPLANTATION, 1998, 21 (08) : 809 - 813
12345