Micromanaging human placental function: differential microRNA expression in feto-placental endothelial cells of gestational diabetes pregnancies

被引：4
|
作者：
Novakovic, Boris
Mansell, Toby
Saffery, Richard [1 ]
机构：
[1] Royal Childrens Hosp, Murdoch Childrens Res Inst, Epigenet Res, Flemington Rd, Parkville, Vic 3052, Australia
来源：
CLINICAL SCIENCE | 2019年 / 133卷 / 02期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
MELLITUS; MECHANISM;
D O I：
10.1042/CS20180901
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Healthy development in utero relies on the appropriate exchange of nutrients and other signalling between the maternal and fetal circulations. Disruption to this fine balance is associated with several pregnancy and adverse birth outcomes, including gestational diabetes mellitus (GDM). This is a complex condition influenced by genetic, environment and potentially epigenetic factors in association with a range of altered developmental outcomes. A recent study, published in Clinical Science, explores miRNAs as a molecular mechanism underpinning the altered function of placental endothelial cells in GDM pregnancies.
引用
收藏
页码：315 / 319
页数：5
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