Gauging the Impact of Cancer Treatment Modalities on Circulating Tumor Cells (CTCs)

被引:12
|
作者
Mathias, Trevor J. [1 ]
Chang, Katarina T. [1 ]
Martin, Stuart S. [2 ,3 ]
Vitolo, Michele I. [2 ,3 ]
机构
[1] Univ Maryland, Grad Program Life Sci, Program Mol Med, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA
[3] Univ Maryland, Sch Med, Stewart Greenebaum NCI Comprehens Canc Ctr, Baltimore, MD 21201 USA
基金
美国国家卫生研究院;
关键词
cancer; metastasis; circulating tumor cells; CTCs; dissemination; chemotherapy; radiotherapy; surgery resection; EPITHELIAL-MESENCHYMAL TRANSITION; STEM-LIKE CELLS; PROSTATE-CANCER; IN-VIVO; HEMATOGENOUS DISSEMINATION; PROGNOSTIC-SIGNIFICANCE; DISEASE PROGRESSION; NEEDLE-BIOPSY; BREAST; METASTASIS;
D O I
10.3390/cancers12030743
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The metastatic cascade consists of multiple complex steps, but the belief that it is a linear process is diminishing. In order to metastasize, cells must enter the blood vessels or body cavities (depending on the cancer type) via active or passive mechanisms. Once in the bloodstream and/or lymphatics, these cancer cells are now termed circulating tumor cells (CTCs). CTC numbers as well as CTC clusters have been used as a prognostic marker with higher numbers of CTCs and/or CTC clusters correlating with an unfavorable prognosis. However, we have very limited knowledge about CTC biology, including which of these cells are ultimately responsible for overt metastatic growth, but due to the fact that higher numbers of CTCs correlate with a worse prognosis; it would seem appropriate to either limit CTCs and/or their dissemination. Here, we will discuss the different cancer treatments which may inadvertently promote the mobilization of CTCs and potential CTC therapies to decrease metastasis.
引用
收藏
页数:20
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