Generation of two iPSC lines, (ICGi015-A and ICGi015-B), by reprogramming peripheral blood mononuclear cells from a patient with Parkinson's disease

被引：2

作者：

Sharipova, D. V. ^{[1
,2
,3
]}

Kovalenko, V. R. ^{[1
]}

Bairamova, E. M. ^{[1
,3
]}

Vartanova, V. A. ^{[1
,3
]}

Grigor'eva, E. V. ^{[1
,2
,3
]}

Vyatkin, Y. V. ^{[3
,5
,6
]}

Khabarova, E. A. ^{[4
]}

Rzaev, D. A. ^{[4
]}

Zakian, S. M. ^{[1
,2
,3
]}

Medvedev, S. P. ^{[1
,2
,3
]}

机构：

[1] Russian Acad Sci, Siberian Branch, Fed Res Ctr, Inst Cytol & Genet, Novosibirsk, Russia

[2] Minist Hlth Russian Federat, EN Meshalkin Natl Med Res Ctr, Novosibirsk, Russia

[3] Novosibirsk State Univ, Novosibirsk, Russia

[4] Fed Neurosurg Ctr, Novosibirsk, Russia

[5] AcademGene LLC, Novosibirsk, Russia

[6] St Laurent Inst, Woburn, MA USA

来源：

STEM CELL RESEARCH | 2019年 / 41卷

基金：

俄罗斯科学基金会;

关键词：

D O I：

10.1016/j.scr.2019.101652

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Studying Parkinson's disease (PD), one of the most common neurodegenerative disorders worldwide, requires different model systems, including patient-specific induced pluripotent stem cell lines. With the help of non-integrating episomal vectors the iPSC lines ICGi015-A and ICGi015-B were generated from blood mononuclear cells of PD patient, carrying three SNPs, associated with PD development. The obtained iPSC lines express pluripotency markers and demonstrate the ability to in vitro differentiate into the three germ layers. These cell lines may be useful for studying molecular mechanisms of PD and for drug screening.

引用

页数：5

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